Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives.

IF 5.7 2区医学 Q1 RHEUMATOLOGY Current Rheumatology Reports Pub Date : 2024-05-01 Epub Date: 2024-02-19 DOI:10.1007/s11926-024-01140-1

Thomas Foret, Virginie Dufrost, Jeremy Lagrange, Patricia Costa, Guillaume Mourey, Thomas Lecompte, Nadine Magy-Bertrand, Veronique Regnault, Stéphane Zuily, Denis Wahl

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Abstract

Purpose of the review: Thrombotic risk assessment in antiphospholipid positive (aPL +) subjects is a major challenge, and the study of in vitro thrombin generation (thrombin generation assays (TGA)) could provide useful information. Activated protein C (APC) sensitivity is involved in thrombotic events in antiphospholipid syndrome patients. We summarized methods used to assess APC sensitivity with TGA and evaluated the prognostic role of APC resistance through literature search.

Recent findings: APC resistance induced by aPL is a complex pathway. Several cross-sectional studies assessed APC sensitivity to understand thrombotic event mechanisms in aPL + subjects. Only one prospective cohort had investigated the prognostic impact of APC resistance in aPL + subjects, with a positive and significant correlation between APC sensitivity and the risk of thrombosis during the follow up (hazard ratio, 6.07 [95% CI, 1.69-21.87]). APC resistance assessed with TGA could be associated with thrombotic events in aPL + subjects.

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抗磷脂抗体阳性受试者凝血酶原生成测定作为个性化血栓风险评估：技术现状与展望。

综述的目的：抗磷脂阳性（aPL +）患者血栓风险评估是一项重大挑战，体外凝血酶生成研究（凝血酶生成测定（TGA））可提供有用的信息。活化蛋白 C（APC）敏感性与抗磷脂综合征患者的血栓事件有关。我们总结了用 TGA 评估 APC 敏感性的方法，并通过文献检索评估了 APC 抗性的预后作用：由 aPL 诱导的 APC 抗性是一个复杂的途径。一些横断面研究评估了 APC 敏感性，以了解 aPL + 受试者的血栓事件机制。只有一项前瞻性队列研究调查了 aPL + 受试者的 APC 耐药性对预后的影响，结果发现 APC 敏感性与随访期间的血栓形成风险呈显著正相关（危险比为 6.07 [95% CI, 1.69-21.87]）。用 TGA 评估的 APC 抗性可能与 aPL + 受试者的血栓事件有关。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

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期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.