[Altered antibody titers in patients with neuromuscular diseases after high-dose intravenous immunoglobulin therapy].

Q4 Medicine Clinical Neurology Pub Date : 2024-03-22 Epub Date: 2024-02-17 DOI:10.5692/clinicalneurol.cn-001895

Wataru Shiraishi, Yukiko Inamori, Ayano Matsuyoshi, Tetsuya Hashimoto

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Abstract

We investigated the changes in antibody titers after intravenous immunoglobulin (IVIg) administration in patients with neuromuscular diseases. Among patients who received IVIg from April 1, 2020, to August 31, 2022, we retrospectively evaluated 15 patients with antibody measurements before and after IVIg administration for any rise in the following antibody levels and examined the data for subsequent changes of false positive results to negative ones. The levels of anti SS-A, anti-thyroglobulin, anti-thyroid peroxidase, anti-glutamic acid decarboxylase, HBs, and HBc antibodies transiently increased after IVIg administration and showed false-positive results. However, levels of rheumatoid factor and anti-nuclear and antineutrophil cytoplasmic antibodies were not elevated. The false-positive results became negative after 3 months. Here, we report on the changes in antibody levels before and after IVIg administration and note that levels of hepatitis B virus-related antibodies and various autoantibodies transiently rise after IVIg administration.

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[大剂量静脉注射免疫球蛋白治疗后神经肌肉疾病患者抗体滴度的改变]。

我们研究了神经肌肉疾病患者静脉注射免疫球蛋白（IVIg）后抗体滴度的变化。在 2020 年 4 月 1 日至 2022 年 8 月 31 日期间接受过静脉注射免疫球蛋白治疗的患者中，我们对 15 名患者在静脉注射免疫球蛋白治疗前后的抗体测定结果进行了回顾性评估，以了解以下抗体水平是否出现上升，并检查数据是否出现假阳性结果转为阴性结果的情况。抗 SS-A、抗甲状腺球蛋白、抗甲状腺过氧化物酶、抗谷氨酸脱羧酶、HBs 和 HBc 抗体的水平在注射 IVIg 后短暂升高，并出现假阳性结果。然而，类风湿因子、抗核抗体和抗中性粒细胞胞浆抗体的水平并未升高。3 个月后，假阳性结果变为阴性。在此，我们报告了注射 IVIg 前后抗体水平的变化，并指出注射 IVIg 后乙肝病毒相关抗体和各种自身抗体水平会短暂升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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