Bilateral tonic pupils secondary to anti-GD2 antibody therapy for neuroblastoma

IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Journal of Aapos Pub Date : 2024-04-01 DOI:10.1016/j.jaapos.2024.103852
Christopher M. Edwards BS , Daniel Elefant MD , Michael S. Isakoff MD , Majida A. Gaffar MD
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Abstract

We report the case of a 12-year-old girl with stage 4 neuroblastoma who developed tonic pupils secondary to immunotherapy with dinutuximab, an anti-GD2 antibody, based on the timeline provided by her mother with regard to onset of symptoms. The patient presented with difficulty reading and chronic dilated pupils bilaterally, according to her mother’s observations over 6 months prior to presentation. Testing with dilute pilocarpine supported our presumption of tonic pupils.

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继发于神经母细胞瘤抗GD2抗体治疗的双侧强直性瞳孔。
我们报告了一例患有神经母细胞瘤 4 期的 12 岁女孩的病例,根据其母亲提供的发病时间表,该女孩在使用抗 GD2 抗体地纽昔单抗(dinutuximab)进行免疫治疗后出现了强直性瞳孔。根据其母亲在发病前 6 个月的观察,患者出现阅读困难和双侧瞳孔长期散大。使用稀释的皮洛卡品进行的测试证实了我们的推测,即瞳孔强直。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Aapos
Journal of Aapos 医学-小儿科
CiteScore
2.40
自引率
12.50%
发文量
159
审稿时长
55 days
期刊介绍: Journal of AAPOS presents expert information on children''s eye diseases and on strabismus as it affects all age groups. Major articles by leading experts in the field cover clinical and investigative studies, treatments, case reports, surgical techniques, descriptions of instrumentation, current concept reviews, and new diagnostic techniques. The Journal is the official publication of the American Association for Pediatric Ophthalmology and Strabismus.
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