Low-sodium diet with adequate water intake improved the clinical efficacy in Ménière's disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-02-20 DOI:10.1080/00016489.2024.2315302

Xia Yang, Caihong Lin, Qingyun Wu, Lvye Li, Xiaofeng Mei

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Abstract

Background: Ménière's disease (MD) is a common idiopathic inner ear disorder in otorhinolaryngology characterized by recurrent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus and ear fullness.

Objective: To study the effects of low-sodium diet with adequate water intake on the clinical efficacy in MD.

Methods: Fifty patients diagnosed with stage-3 unilateral MD were randomly divided into control group(n = 25) and experimental group(n = 25). The control group was given routine medication therapy, and the experimental group was restricted to an sodium intake of 1500 mg/d and a water intake of 35 ml/kg/d based in addition to the routine medication therapy. The two groups were assessed using pure tone audiometry, electrocochleography, Tinnitus Handicap Inventory (THI), and Dizziness Handicap Inventory (DHI).

Results: The pure tone audiometry and electrocochleography showed better improvements after treatment in the experimental group than the control group (p < 0.05). The THI improved values in the experimental group were significantly higher than the control group (p < 0.001). The DHI improved values in the experimental group were significantly higher than the control group (p = 0.004).

Conclusions and significance: Low-sodium diet with adequate water intake improved the hearing and alleviated vertigo and tinnitus in MD patients.

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低钠饮食与充足的水摄入可提高梅尼埃病的临床疗效。

背景：梅尼埃病（MD）是耳鼻喉科常见的特发性内耳疾病，以反复发作的眩晕、波动性感音神经性听力损失、耳鸣和耳胀满为特征：研究低钠饮食与充足的水摄入对 MD 临床疗效的影响：方法：将 50 名确诊为 3 期单侧 MD 的患者随机分为对照组（25 人）和实验组（25 人）。对照组给予常规药物治疗，实验组除常规药物治疗外，限制钠摄入量为 1500 mg/d，水摄入量为 35 ml/kg/d。使用纯音测听仪、耳电图、耳鸣障碍量表（THI）和头晕障碍量表（DHI）对两组患者进行评估：结果：实验组的纯音测听和耳电图显示，治疗后实验组比对照组有更好的改善（P P = 0.004）：结论与意义：低钠饮食与充足的水摄入可改善 MD 患者的听力，缓解眩晕和耳鸣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.