A Systematic Review of the Impact of Resveratrol on Viral Hepatitis and Chronic Viral Hepatitis-related Hepatocellular Carcinoma.

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current molecular medicine Pub Date : 2024-02-19 DOI:10.2174/0115665240284347240125072555

Mohammad Darvishi, Majid Nouri, Rasoul Rahimi, Saeid Heidari-Soureshjani, Seyed Mahmood Reza Hashemi Rafsanjani

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Abstract

Background: Resveratrol (RSV) is used for the treatment of various diseases due to their anti-inflammatory and antioxidant activities. However, its beneficial aspects on viral hepatitis have been less investigated.

Objective: This report reviews the impact of resveratrol on viral hepatitis and chronic viral hepatitis-related hepatocellular carcinoma (HCC).

Methods: The systematic review was performed and reported according to the PRISMA 2020 statement. Several core databases, such as Cochrane Library, PubMed, Web of Science, EMBASE, and Scopus, were used for search on September 6, 2023. After extraction of the data, the desired information of the full text of the studies was recorded in Excel, and the outcomes and mechanisms were reviewed.

Results: RSV inhibits viral replication through anti-HCV NS3 helicase activity, maintains redox homeostasis via glutathione (GSH) synthesis, improves T and B cell activity, and suppresses miR-155 expression. It also enhances viral replication by enhancing hepatitis C virus (HCV) RNA transcription, activating sirtuin-1 (SIRT1), which can increase peroxisome proliferator-activated receptor (PPAR), and SIRT1 activates the HBV X protein (HBx). Moreover, RSV is responsible for hepatitis-related HCC proliferation via suppression of mammalian target of rapamycin (mTOR), SIRT1 up-regulation, inhibiting expression of HBx, and reducing expression of cyclin D1.

Conclusion: Despite the promising properties of RSV in inhibiting hepatitis-related HCC cell proliferation, its antiviral effects in viral hepatitis are controversial. The antihepatitis behaviors of RSV are mainly dose-dependent, and in some studies, activating some hepatoprotective pathways increases the transcription and replication of chronic HBV and HCV. Therefore, healthcare providers should be aware of viral hepatitis before using RSV supplements.

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白藜芦醇对病毒性肝炎和慢性病毒性肝炎相关肝细胞癌影响的系统性综述

背景：白藜芦醇（RSV）具有抗炎和抗氧化活性，可用于治疗多种疾病。然而，人们对其对病毒性肝炎的益处研究较少：本报告回顾了白藜芦醇对病毒性肝炎和慢性病毒性肝炎相关肝细胞癌（HCC）的影响：方法：根据 PRISMA 2020 声明进行系统综述和报告。2023 年 9 月 6 日，使用 Cochrane Library、PubMed、Web of Science、EMBASE 和 Scopus 等多个核心数据库进行检索。提取数据后，将所需的研究全文信息录入Excel，并对研究结果和机制进行回顾：RSV通过抗HCV NS3螺旋酶活性抑制病毒复制，通过谷胱甘肽（GSH）合成维持氧化还原平衡，提高T细胞和B细胞活性，抑制miR-155的表达。它还通过增强丙型肝炎病毒（HCV）RNA 转录、激活 sirtuin-1 （SIRT1）（SIRT1 可增加过氧化物酶体增殖激活受体（PPAR））以及 SIRT1 激活 HBV X 蛋白（HBx）来增强病毒复制。此外，RSV 通过抑制哺乳动物雷帕霉素靶标（mTOR）、SIRT1 上调、抑制 HBx 的表达和减少细胞周期蛋白 D1 的表达，对肝炎相关的 HCC 增殖负责：尽管 RSV 在抑制肝炎相关的 HCC 细胞增殖方面具有良好的特性，但其在病毒性肝炎中的抗病毒作用仍存在争议。RSV的抗肝炎行为主要是剂量依赖性的，在一些研究中，激活某些保肝途径会增加慢性HBV和HCV的转录和复制。因此，医疗保健提供者在使用 RSV 补充剂前应了解病毒性肝炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.