{"title":"FGF21 suppresses CD8+ T cell antitumour activity","authors":"Olivia Tysoe","doi":"10.1038/s41574-024-00964-2","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Research in Toxicology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41574-024-00964-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
肿瘤可以通过抑制肿瘤微环境（TME）中免疫细胞的活性来躲避免疫系统，其中细胞毒性 CD8+ T 细胞是免疫抑制的一个关键靶点。细胞新陈代谢》（Cell Metabolism）杂志上的一项研究发现了成纤维细胞生长因子21（FGF21）通过抑制CD8+ T细胞活性促进肿瘤生长的机制。与用对照培养基处理的 T 细胞相比，用中药处理的 T 细胞产生的 IFNγ 和颗粒酶 B 等分子大大减少。这一发现表明，T细胞的功能受到了肿瘤分泌因子的抑制。通过蛋白质组分析，研究人员发现，与对照培养基相比，FGF21是中药中持续上调的因子。与来自同一人的健康组织样本相比，来自结肠癌患者的肿瘤样本同样显示出 FGF21 的表达增加。
期刊介绍：
Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.
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