Modified Method for Nanothin Descemet Stripping Automated Endothelial Keratoplasty.

IF 1.9 3区医学 Q2 OPHTHALMOLOGY Cornea Pub Date : 2024-12-01 DOI:10.1097/ICO.0000000000003507

Zelin Zhao, Lei Lin, Weihe Zhou, Jiaqi Chen, Yinling Xiao, Vishal Jhanji, Yang Liu, Qinxiang Zheng, Wei Chen

{"title":"Modified Method for Nanothin Descemet Stripping Automated Endothelial Keratoplasty.","authors":"Zelin Zhao, Lei Lin, Weihe Zhou, Jiaqi Chen, Yinling Xiao, Vishal Jhanji, Yang Liu, Qinxiang Zheng, Wei Chen","doi":"10.1097/ICO.0000000000003507","DOIUrl":null,"url":null,"abstract":"Purpose: The purpose of this study was to describe a method to achieve a high success rate for nanothin (NT, ≤50 μm) Descemet stripping automated endothelial keratoplasty (DSAEK) graft preparation using anterior chamber pressurizer (ACP) with a modified setting and evaluate its postoperative efficacy.Methods: A prospective cohort (study group) of 24 patients with corneal endothelial dysfunction was consecutively enrolled and received DSAEK grafts using the modified ACP method from December 2021 to May 2022. The control group included 24 historical patients who received DSAEK grafts using conventional ACP procedure. Central graft thickness (CGT), graft regularity (3-mm and 5-mm diameter zones), best spectacle-corrected visual acuity, and endothelial cell density (ECD) were compared between 2 groups.Results: A 100% ultrathin (UT, ≤100 μm) DSAEK rate and 62.5% NT-DSAEK rate was achieved at 3 months postsurgery in the study group, with a 51.3 ± 14.8 μm CGT, while a 70.8% UT-DSAEK rate and 4.2% NT-DSAEK rate was achieved in the control group, with an 89.0 ± 15.4 μm CGT ( P <0.001). At 3-month postoperative follow-up, the regularity of graft thickness was significantly better in the study group (central-to-peripheral thickness difference: P = 0.044 and 0.014 for 3-mm and 5-mm diameter zones, respectively, graft thickness uniformity: P <0.001 and 0.012, respectively). There was no statistical difference in the best spectacle-corrected visual acuity ( P = 0.170) or ECD ( P = 0.833) between 2 groups at 3-month postoperative follow-up.Conclusions: DSAEK grafts harvested using modified ACP method were thinner and more regular compared with the conventional ACP method.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"1522-1527"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cornea","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ICO.0000000000003507","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The purpose of this study was to describe a method to achieve a high success rate for nanothin (NT, ≤50 μm) Descemet stripping automated endothelial keratoplasty (DSAEK) graft preparation using anterior chamber pressurizer (ACP) with a modified setting and evaluate its postoperative efficacy.

Methods: A prospective cohort (study group) of 24 patients with corneal endothelial dysfunction was consecutively enrolled and received DSAEK grafts using the modified ACP method from December 2021 to May 2022. The control group included 24 historical patients who received DSAEK grafts using conventional ACP procedure. Central graft thickness (CGT), graft regularity (3-mm and 5-mm diameter zones), best spectacle-corrected visual acuity, and endothelial cell density (ECD) were compared between 2 groups.

Results: A 100% ultrathin (UT, ≤100 μm) DSAEK rate and 62.5% NT-DSAEK rate was achieved at 3 months postsurgery in the study group, with a 51.3 ± 14.8 μm CGT, while a 70.8% UT-DSAEK rate and 4.2% NT-DSAEK rate was achieved in the control group, with an 89.0 ± 15.4 μm CGT ( P <0.001). At 3-month postoperative follow-up, the regularity of graft thickness was significantly better in the study group (central-to-peripheral thickness difference: P = 0.044 and 0.014 for 3-mm and 5-mm diameter zones, respectively, graft thickness uniformity: P <0.001 and 0.012, respectively). There was no statistical difference in the best spectacle-corrected visual acuity ( P = 0.170) or ECD ( P = 0.833) between 2 groups at 3-month postoperative follow-up.

Conclusions: DSAEK grafts harvested using modified ACP method were thinner and more regular compared with the conventional ACP method.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

改进的纳米蛋白脱丝剥离自动内皮角膜移植术方法。

目的：本研究的目的是描述一种使用改良设置的前房加压器（ACP）进行纳米素（NT，≤50 μm）Descemet剥离自动内皮角膜成形术（DSAEK）移植物制备的高成功率方法，并评估其术后疗效：前瞻性队列（研究组）连续招募了24名角膜内皮功能障碍患者，并于2021年12月至2022年5月期间使用改良的ACP方法接受了DSAEK移植物。对照组包括 24 名使用传统 ACP 程序接受 DSAEK 移植物的历史患者。两组患者的中央移植物厚度（CGT）、移植物规则性（3毫米和5毫米直径区域）、最佳眼镜矫正视力和内皮细胞密度（ECD）进行了比较：研究组术后3个月的超薄（UT，≤100 μm）DSAEK率为100%，NT-DSAEK率为62.5%，CGT为51.3 ± 14.8 μm；对照组术后3个月的超薄（UT，≤100 μm）DSAEK率为70.8%，NT-DSAEK率为4.2%，CGT为89.0 ± 15.4 μm（P 结论：研究组术后3个月的超薄（UT，≤100 μm）DSAEK率为100%，NT-DSAEK率为62.5%，CGT为51.3 ± 14.8 μm：与传统 ACP 方法相比，使用改良 ACP 方法采集的 DSAEK 移植物更薄、更规则。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cornea 医学-眼科学

CiteScore

5.20

自引率

10.70%

发文量

354

审稿时长

3-6 weeks

期刊介绍： For corneal specialists and for all general ophthalmologists with an interest in this exciting subspecialty, Cornea brings together the latest clinical and basic research on the cornea and the anterior segment of the eye. Each volume is peer-reviewed by Cornea''s board of world-renowned experts and fully indexed in archival format. Your subscription brings you the latest developments in your field and a growing library of valuable professional references. Sponsored by The Cornea Society which was founded as the Castroviejo Cornea Society in 1975.