The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females

IF 4.3 2区医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2024-02-20 DOI:10.1016/j.ynstr.2024.100618

Megan E. Castle, Meghan E. Flanigan

{"title":"The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females","authors":"Megan E. Castle, Meghan E. Flanigan","doi":"10.1016/j.ynstr.2024.100618","DOIUrl":null,"url":null,"abstract":"<div><p>Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide, but current treatments are insufficient in fully addressing the symptoms that often lead to relapses in alcohol consumption. The brain's serotonin system has been implicated in AUD for decades and is a major regulator of stress-related behaviors associated with increased alcohol consumption. This review will discuss the current literature on the association between neurobiological adaptations in serotonin systems and AUD in humans as well as the effectiveness of serotonin receptor manipulations on alcohol-related behaviors like consumption and withdrawal. We will further discuss how these findings in humans relate to findings in animal models, including a comparison of systemic pharmacological manipulations modulating alcohol consumption. We next provide a detailed overview of brain region-specific roles for serotonin and serotonin receptor signaling in alcohol-related behaviors in preclinical animal models, highlighting the complexity of forming a cohesive model of serotonin function in AUD and providing possible avenues for more effective therapeutic intervention. Throughout the review, we discuss what is known about sex differences in the sequelae of AUD and the role of serotonin in these sequelae. We stress a critical need for additional studies in women and female animals so that we may build a clearer path to elucidating sex-specific serotonergic mechanisms and develop better treatments.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352289524000146/pdfft?md5=b7a33519ad2ef67f75c6ec52ad7504cc&pid=1-s2.0-S2352289524000146-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobiology of Stress","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352289524000146","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide, but current treatments are insufficient in fully addressing the symptoms that often lead to relapses in alcohol consumption. The brain's serotonin system has been implicated in AUD for decades and is a major regulator of stress-related behaviors associated with increased alcohol consumption. This review will discuss the current literature on the association between neurobiological adaptations in serotonin systems and AUD in humans as well as the effectiveness of serotonin receptor manipulations on alcohol-related behaviors like consumption and withdrawal. We will further discuss how these findings in humans relate to findings in animal models, including a comparison of systemic pharmacological manipulations modulating alcohol consumption. We next provide a detailed overview of brain region-specific roles for serotonin and serotonin receptor signaling in alcohol-related behaviors in preclinical animal models, highlighting the complexity of forming a cohesive model of serotonin function in AUD and providing possible avenues for more effective therapeutic intervention. Throughout the review, we discuss what is known about sex differences in the sequelae of AUD and the role of serotonin in these sequelae. We stress a critical need for additional studies in women and female animals so that we may build a clearer path to elucidating sex-specific serotonergic mechanisms and develop better treatments.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

大脑血清素信号在过度饮酒和戒酒中的作用：呼吁对女性进行更多研究

酒精使用障碍（AUD）是导致全球死亡和残疾的一个主要原因，但目前的治疗方法不足以完全解决经常导致酒精消费复发的症状。几十年来，大脑的血清素系统一直与 AUD 有关，它是与酒精消费增加有关的压力相关行为的主要调节器。本综述将讨论血清素系统的神经生物学适应性与人类 AUD 之间关联的现有文献，以及操纵血清素受体对酒精相关行为（如饮酒和戒酒）的有效性。我们将进一步讨论这些人类研究结果与动物模型研究结果之间的关系，包括对调节酒精消耗的系统药理作用进行比较。接下来，我们将详细概述临床前动物模型中血清素和血清素受体信号传导在酒精相关行为中的脑区特异性作用，突出强调在 AUD 中形成血清素功能凝聚模型的复杂性，并为更有效的治疗干预提供可能的途径。在整篇综述中，我们讨论了有关 AUD 后遗症的性别差异以及血清素在这些后遗症中的作用的已知情况。我们强调亟需在女性和雌性动物中开展更多研究，从而为阐明性别特异性血清素能机制和开发更好的治疗方法开辟一条更清晰的道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

9.40

自引率

4.00%

发文量

审稿时长

48 days

期刊介绍： Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.