The relevance of the superior cervical ganglion for cardiac autonomic innervation in health and disease: a systematic review.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI:10.1007/s10286-024-01019-2
H Sophia Chen, Lieke van Roon, Yang Ge, Janine M van Gils, Jan W Schoones, Marco C DeRuiter, Katja Zeppenfeld, Monique R M Jongbloed
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Abstract

Purpose: The heart receives cervical and thoracic sympathetic contributions. Although the stellate ganglion is considered the main contributor to cardiac sympathetic innervation, the superior cervical ganglia (SCG) is used in many experimental studies. The clinical relevance of the SCG to cardiac innervation is controversial. We investigated current morphological and functional evidence as well as controversies on the contribution of the SCG to cardiac innervation.

Methods: A systematic literature review was conducted in PubMed, Embase, Web of Science, and COCHRANE Library. Included studies received a full/text review and quality appraisal.

Results: Seventy-six eligible studies performed between 1976 and 2023 were identified. In all species studied, morphological evidence of direct or indirect SCG contribution to cardiac innervation was found, but its contribution was limited. Morphologically, SCG sidedness may be relevant. There is indirect functional evidence that the SCG contributes to cardiac innervation as shown by its involvement in sympathetic overdrive reactions in cardiac disease states. A direct functional contribution was not found. Functional data on SCG sidedness was largely unavailable. Information about sex differences and pre- and postnatal differences was lacking.

Conclusion: Current literature mainly supports an indirect involvement of the SCG in cardiac innervation, via other structures and plexuses or via sympathetic overdrive in response to cardiac diseases. Morphological evidence of a direct involvement was found, but its contribution seems limited. The relevance of SCG sidedness, sex, and developmental stage in health and disease remains unclear and warrants further exploration.

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颈上神经节与健康和疾病中心脏自主神经支配的相关性:系统综述。
目的:心脏接受颈部和胸部交感神经的支配。尽管星状神经节被认为是心脏交感神经支配的主要来源,但许多实验研究都使用了上颈神经节(SCG)。上颈神经节与心脏交感神经支配的临床相关性还存在争议。我们调查了目前有关 SCG 对心脏神经支配的贡献的形态和功能证据以及争议:方法:我们在 PubMed、Embase、Web of Science 和 COCHRANE 图书馆中进行了系统的文献综述。对纳入的研究进行了全文审阅和质量评估:结果:共发现 76 项符合条件的研究,这些研究是在 1976 年至 2023 年间进行的。在研究的所有物种中,都发现了 SCG 直接或间接影响心脏神经支配的形态学证据,但其影响有限。从形态学角度看,SCG 的两侧性可能与此有关。有间接的功能性证据表明,SCG 对心脏神经支配有贡献,因为它参与了心脏疾病状态下的交感神经过度驱动反应。但没有发现直接的功能性贡献。有关 SCG 边度的功能数据基本没有。缺乏有关性别差异和出生前后差异的信息:目前的文献主要支持 SCG 通过其他结构和神经丛间接参与心脏神经支配,或通过交感神经过度驱动来应对心脏疾病。虽然发现了直接参与的形态学证据,但其作用似乎有限。SCG的侧性、性别和发育阶段与健康和疾病的相关性仍不清楚,值得进一步探讨。
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7.20
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4.30%
发文量
567
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