Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies.

IF 3.2 4区医学 Q3 CHEMISTRY, MEDICINAL Future medicinal chemistry Pub Date : 2024-04-01 Epub Date: 2024-02-23 DOI:10.4155/fmc-2023-0249

Thiago H Fermiano, João V Perez de Souza, Letícia S Murase, João P Salvaterra Pasquini, Regiane B de Lima Scodro, Paula A Zanetti Campanerut-Sá, Katiany Rizzieri Caleffi-Ferracioli, Vera L Dias Siqueira, Jean E Meneguello, Jorge J Vieira Teixeira, Rosilene Fressatti Cardoso

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Abstract

Background: The scope of the study was to analyze original preclinical studies on the antimicrobial effects of carvacrol and derivatives on the Mycobacterium genus. Materials & methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, four databases (PubMed, Web of Science, SCOPUS and EMBASE) were searched. Results: The search retrieved 392 records, of which 11 papers were selected. Heterogeneity in the techniques and mycobacterial targets was observed. Carvacrol demonstrated synergistic antimycobacterial activity with rifampicin against multidrug-resistant Mycobacterium tuberculosis on membranes and biofilms. In silico approaches showed specific targets in mycobacteria, by inhibition and molecular docking assays, on the enzyme chorismate mutase and the heat shock protein 16.3. Conclusion: Carvacrol has been shown to be a scaffold candidate for future molecules with activity against mycobacteria.

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香芹酚及其衍生物对分枝杆菌属的抗菌活性：临床前研究的系统回顾。

背景：本研究的范围是分析有关香芹酚及其衍生物对分枝杆菌抗菌作用的原始临床前研究。材料与方法：根据《系统综述和荟萃分析首选报告项目》声明，检索了四个数据库（PubMed、Web of Science、SCOPUS 和 EMBASE）。结果：检索到 392 条记录，其中 11 篇论文被选中。观察到了技术和霉菌靶标的异质性。香芹酚与利福平对膜和生物膜上的耐多药结核分枝杆菌具有协同抗分枝杆菌活性。通过抑制和分子对接试验，硅学方法显示了该药物在分枝杆菌中的特异性靶点--胆氨酸突变酶和热休克蛋白 16.3。结论研究表明，香芹酚是未来具有抗分枝杆菌活性分子的候选支架。

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来源期刊

Future medicinal chemistry CHEMISTRY, MEDICINAL-

CiteScore

5.80

自引率

2.40%

发文量

118

审稿时长

4-8 weeks

期刊介绍： Future Medicinal Chemistry offers a forum for the rapid publication of original research and critical reviews of the latest milestones in the field. Strong emphasis is placed on ensuring that the journal stimulates awareness of issues that are anticipated to play an increasingly central role in influencing the future direction of pharmaceutical chemistry. Where relevant, contributions are also actively encouraged on areas as diverse as biotechnology, enzymology, green chemistry, genomics, immunology, materials science, neglected diseases and orphan drugs, pharmacogenomics, proteomics and toxicology.