Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-07 DOI:10.3390/hematolrep16010008

Masaya Morimoto, Yuma Yokoya, Kikuaki Yoshida, Hideki Kosako, Yoshikazu Hori, Toshiki Mushino, Shinobu Tamura, Reiko Ito, Ryosuke Koyamada, Takuya Yamashita, Shinichiro Mori, Nobuyoshi Mori, Sachiko Ohde

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Abstract

Febrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN in patients with DLBCL. In this multicenter, retrospective, observational analysis, a multivariate logistic regression model was used to analyze the association between FN incidence and pretreatment clinical factors. We included adult inpatients and outpatients (aged ≥ 18 years) diagnosed with DLBCL who were treated with chemotherapy. The study examined 246 patients. Considering FN occurring during the first cycle of chemotherapy as the primary outcome, a predictive model with a total score of 5 points was constructed as follows: 1 point each for a positive hepatitis panel, extranodal involvement, and a high level of soluble interleukin-2 receptor and 2 points for lymphopenia. The area under the receiver operating characteristic curve of this model was 0.844 (95% confidence interval: 0.777-0.911). Our predictive model can assess the risk of FN before patients with DLBCL start chemotherapy, leading to better outcomes.

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弥漫大 B 细胞淋巴瘤患者化疗后出现发热性中性粒细胞减少症的预测模型：一项多中心、回顾性、观察性研究。

发热性中性粒细胞减少症（FN）是弥漫大B细胞淋巴瘤（DLBCL）患者接受化疗时的一个主要问题；然而，FN的总体风险却很难评估。本研究旨在建立一个模型，用于预测弥漫性大 B 细胞淋巴瘤患者 FN 的发生。在这项多中心、回顾性、观察性分析中，我们采用了多变量逻辑回归模型来分析FN发生率与治疗前临床因素之间的关系。我们纳入了接受化疗的DLBCL成人住院和门诊患者（年龄≥18岁）。研究共对246名患者进行了检查。将化疗第一周期发生的 FN 作为主要结果，构建了一个总分为 5 分的预测模型，具体如下：肝炎阳性、结节外受累和可溶性白细胞介素-2 受体水平高各占 1 分，淋巴细胞减少占 2 分。该模型的接收器操作特征曲线下面积为 0.844（95% 置信区间：0.777-0.911）。我们的预测模型可以在DLBCL患者开始化疗前评估FN的风险，从而获得更好的治疗效果。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.