Investigating the Role of Non-Coding RNA in Non-Alcoholic Fatty Liver Disease.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2024-01-31 DOI:10.3390/ncrna10010010

Samar A Zailaie, Basmah B Khoja, Jumana J Siddiqui, Mohammad H Mawardi, Emily Heaphy, Amjad Aljagthmi, Consolato M Sergi

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Abstract

Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein but play key roles in regulating cellular processes. NcRNAs globally affect gene expression in diverse physiological and pathological contexts. Functionally important ncRNAs act in chromatin modifications, in mRNA stabilization and translation, and in regulation of various signaling pathways. Non-alcoholic fatty liver disease (NAFLD) is a set of conditions caused by the accumulation of triacylglycerol in the liver. Studies of ncRNA in NAFLD are limited but have demonstrated that ncRNAs play a critical role in the pathogenesis of NAFLD. In this review, we summarize NAFLD's pathogenesis and clinical features, discuss current treatment options, and review the involvement of ncRNAs as regulatory molecules in NAFLD and its progression to non-alcoholic steatohepatitis (NASH). In addition, we highlight signaling pathways dysregulated in NAFLD and review their crosstalk with ncRNAs. Having a thorough understanding of the disease process's molecular mechanisms will facilitate development of highly effective diagnostic and therapeutic treatments. Such insights can also inform preventive strategies to minimize the disease's future development.

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研究非编码 RNA 在非酒精性脂肪肝中的作用

非编码 RNA（ncRNA）是不编码蛋白质的 RNA 分子，但在调节细胞过程中发挥着关键作用。在不同的生理和病理环境中，NcRNA 会全面影响基因表达。功能重要的 ncRNA 在染色质修饰、mRNA 稳定和翻译以及各种信号通路的调控中发挥作用。非酒精性脂肪肝（NAFLD）是由三酰甘油在肝脏中蓄积引起的一系列疾病。对非酒精性脂肪肝中 ncRNA 的研究有限，但已证明 ncRNA 在非酒精性脂肪肝的发病机制中起着关键作用。在这篇综述中，我们总结了非酒精性脂肪肝的发病机制和临床特征，讨论了当前的治疗方案，并回顾了 ncRNA 作为调控分子参与非酒精性脂肪肝及其向非酒精性脂肪性肝炎（NASH）发展的过程。此外，我们还强调了非酒精性脂肪肝中失调的信号通路，并回顾了它们与 ncRNA 的相互影响。透彻了解疾病过程的分子机制将有助于开发高效的诊断和治疗方法。这些见解还可以为预防策略提供依据，从而最大限度地减少疾病的未来发展。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.

期刊最新文献

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