Vitamin D and follicular recruitment in the in vitro fertilization cycle.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-06-01 DOI:10.5935/1518-0557.20240005
Roberto de A Antunes, Brenda M L de Melo, Maria do Carmo B de Souza, Marcelo M de Souza, Gabriela P S Melo, Thamires F M Jandre, Ana Cristina A Mancebo, Flavia L Conceição, Tania M Ortiga-Carvalho
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Abstract

Objective: Vitamin D (VD) is a fat-soluble steroid hormone, synthesized by the skin, most known for its role in bone mineral balance. Vitamin D receptors (VDR) are also found in the female reproductive system, but their role remains unclear. The objective of this study was to analyze the relationship between serum vitamin D levels and the number of oocytes retrieved after ovarian stimulation.

Methods: This is a retrospective study involving 267 patients undergoing in vitro fertilization (IVF) carried out in the Fertipraxis clinic, a private practice facility. The patients were initially divided into two groups according to their VD levels. Group 1 included 152 patients with VD levels < 30 ng/mL and group 2 had 115 patients with VD levels > 30 ng/mL. They were further analyzed and separated considering their age, anthropometric data, ovarian reserve, amount of gonadotropin used, and follicles obtained until trigger day.

Results: In our analysis, there were no difference in the number of follicles and oocytes retrieved, nor in the number of mature oocytes obtained from patients with both vitamin D deficiency and sufficiency.

Conclusions: The results of our study show no difference among number of follicles, oocytes retrieved and mature oocytes obtained after ovarian stimulation according to their vitamin D serum levels. Further higher-quality studies are needed to evaluate the possible roles of serum vitamin D levels in other stages of human fertilization process.

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维生素 D 与体外受精周期中的卵泡募集。
目的:维生素 D(VD)是一种脂溶性类固醇激素,由皮肤合成:维生素 D(VD)是一种脂溶性类固醇激素,由皮肤合成,因其在骨矿物质平衡中的作用而闻名。女性生殖系统中也存在维生素 D 受体(VDR),但其作用尚不明确。本研究旨在分析血清维生素 D 水平与卵巢刺激后获取的卵母细胞数量之间的关系:这是一项回顾性研究,涉及 267 名在私人诊所 Fertipraxis 进行体外受精(IVF)的患者。最初根据患者的 VD 水平将其分为两组。第一组包括 152 名 VD 水平小于 30 纳克/毫升的患者,第二组包括 115 名 VD 水平大于 30 纳克/毫升的患者。我们根据患者的年龄、人体测量数据、卵巢储备功能、促性腺激素用量以及触发日之前获得的卵泡数量对两组患者进行了进一步分析和区分:在我们的分析中,维生素 D 缺乏和维生素 D 充足的患者所获得的卵泡和卵母细胞数量以及成熟卵母细胞数量均无差异:我们的研究结果表明,卵巢刺激后的卵泡数、取卵细胞数和成熟卵母细胞数在维生素 D 血清水平上没有差异。需要进一步开展更高质量的研究,以评估血清维生素 D 水平在人类受精过程的其他阶段可能发挥的作用。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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