Primary Oral Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature.

IF 3.2 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2024-02-23 DOI:10.1007/s12105-024-01613-w

Pawat Sripodok, Atsumu Kouketsu, Kanako Kuroda, Hitoshi Miyashita, Tsuyoshi Sugiura, Hiroyuki Kumamoto

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Abstract

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains exceptionally rare. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy. The resected specimen showed two distinct components of NEC and squamous cell carcinoma (SCC) with the confirmation of immunohistochemical markers. There has been no sign of recurrence nor metastasis 6 years after the surgery. In addition, we have conducted a review of published cases with potential relevance to this entity, resulting in five cases. The diverse terminology reinforces the need for a standardized classification system of oral/head and neck MiNENs.

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原发性口腔神经内分泌-非神经内分泌混合肿瘤（MiNEN）：罕见病例报告和文献综述。

神经内分泌-非神经内分泌混合瘤（MiNENs）是最近出现的一种罕见肿瘤，其特点是在同一肿瘤组织中同时存在神经内分泌和非神经内分泌成分。尽管米内皮瘤在世界卫生组织的各种器官分类中占有一席之地，但头颈部的这种复合肿瘤仍然异常罕见。我们报告了一例原发性口腔米网状瘤，患者为一名 64 岁男性，位于左侧下牙龈。活检结果令人怀疑是神经内分泌癌（NEC），患者接受了下颌骨部分切除术。经免疫组化标记确认，切除的标本显示出神经内分泌癌和鳞状细胞癌（SCC）两种不同的成分。术后 6 年未见复发或转移迹象。此外，我们还对已发表的可能与该病例相关的病例进行了回顾，共发现了五例病例。不同的术语加强了建立口腔/头颈部米纳恩标准化分类系统的必要性。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.