Vaccine effectiveness in preventing deaths in people with severe acute respiratory syndrome due to COVID-19 in Blumenau, Brazil, 2021.

IF 2.5 Q1 Multidisciplinary Epidemiologia e Servicos de Saude Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI:10.1590/S2237-96222024v33e2023214.en

Emanuelle Renck, Caroline Beatriz Zipper, Marcio Rodrigues Fabrino Junior, Luisa Andrea Torres Salgado, Adriel Rowe, Ernani Tiaraju de Santa Helena

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Abstract

Objective: to analyze the vaccine effectiveness in preventing deaths attributed to severe acute respiratory syndrome due to COVID-19 (SARS/COVID-19) in adults and the elderly, in Blumenau, state of Santa Catarina, Brazil, 2021.

this was a population-based study conducted among individuals aged 20 years and older hospitalized with SARS/COVID-19; each death due to SARS/COVID-19 was considered a "case", and every survivor was considered a "control"; the association between vaccination status and the outcome of "death" was estimated using logistic regression, and vaccine effectiveness was estimated as (1-OR)*100.

The study included 1,756 cases of SARS/COVID-19 (59.2% male, mean age of 56 years, 50.4% with elementary education, 68.4% with comorbidities and 39.1% in intensive care), of whom 398 died (cases) and 1,358 survived (controls); vaccine effectiveness was 74% and 85% (20-59 years old) and 72% and 75% (≥ 60 years old), respectively, for those who were partially vaccinated and fully vaccinated.

Conclusion: vaccines proved to be effective in reducing case fatality ratio due to SARS/COVID-19 in individuals ≥ 20 years old.

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2021 年在巴西布卢梅瑙接种疫苗预防 COVID-19 引起的严重急性呼吸道综合征患者死亡的有效性。

目的：分析 2021 年巴西圣卡塔琳娜州布卢梅瑙市预防 COVID-19 引起的严重急性呼吸系统综合征（SARS/COVID-19）导致成人和老年人死亡的疫苗效果。这是一项以人口为基础的研究，研究对象是因 SARS/COVID-19 而住院的 20 岁及以上的人，每一个因 SARS/COVID-19 而死亡的人被视为一个 "病例"，每一个幸存者被视为一个 "对照"；疫苗接种情况与 "死亡 "结果之间的关系是通过逻辑回归来估算的，疫苗效果是通过 (1-OR)*100 来估算的。该研究包括 1 756 例 SARS/COVID-19 病例（59.2% 为男性，平均年龄 56 岁，50.4% 受过初等教育，68.4% 有合并症，39.结论：事实证明，疫苗能有效降低 20 岁以上人群因 SARS/COVID-19 导致的病死率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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