A novel marker for prediabetic conditions: Uric acid-to-HDL cholesterol ratio.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2023_130

Sumeyye Buse Balci, Burcin Meryem Atak, Tuba Duman, Feyza Nihal Ozkul, Gulali Aktas

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Abstract

Objectives: The objective of this study was to identify a parameter that can facilitate the diagnosis of prediabetes and predict the likelihood of its development in individuals at high risk.

Methods: In this retrospective study, the study population was selected from Bolu Abant Izzet Baysal University Hospital's patients. Participants were divided into two groups, prediabetes and healthy group. We excluded individuals with certain conditions or taking certain medications. The study compared the ratios of uric acid to high-density lipoprotein (HDL) between the two groups and identified the optimal point of differentiation.

Results: The study analyzed data from 228 individuals, including 125 with prediabetes and 103 healthy controls. Those with prediabetes had a significantly higher median UHR (0.13 (0.07-0.24) %) compared to healthy individuals (0.09 (0.05-0.16) %) (p < 0.001). Higher UHR values were associated with a greater risk of prediabetes. A UHR cut-off points greater than 0.11 % had a sensitivity of 74 % and specificity of 69 % in detecting prediabetes.

Conclusion: The study provides evidence that UHR can serve as a practical and valuable diagnostic and screening tool for prediabetes (Tab. 2, Fig. 1, Ref. 23). Text in PDF www.elis.sk Keywords: serum uric acid, HDL cholesterol, UHR, prediabetes.

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糖尿病前期症状的新型标记物：尿酸与高密度脂蛋白胆固醇的比率。

研究目的本研究的目的是确定一个有助于诊断糖尿病前期和预测高危人群糖尿病发展可能性的参数：在这项回顾性研究中，研究对象选自博卢阿班特-伊扎特-拜萨尔大学医院的患者。参与者被分为两组，即糖尿病前期组和健康组。我们排除了患有某些疾病或正在服用某些药物的人。研究比较了两组患者尿酸与高密度脂蛋白（HDL）的比率，并确定了最佳区分点：研究分析了 228 人的数据，其中包括 125 名糖尿病前期患者和 103 名健康对照者。与健康人（0.09 (0.05-0.16) %）相比，糖尿病前期患者的 UHR 中位数（0.13 (0.07-0.24) %）明显更高（p < 0.001）。UHR 值越高，患糖尿病前期的风险越大。在检测糖尿病前期方面，UHR 临界点大于 0.11 % 的灵敏度为 74 %，特异度为 69 %：本研究提供的证据表明，UHR 可作为诊断和筛查糖尿病前期的实用且有价值的工具（表 2，图 1，参考文献 23）。Text in PDF www.elis.sk Keywords: serum uric acid, HDL cholesterol, UHR, prediabetes.

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来源期刊

Bratislava Medical Journal-Bratislavske Lekarske Listy 医学-医学：内科

CiteScore

2.60

自引率

0.00%

发文量

185

审稿时长

3-8 weeks

期刊介绍： The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.