Mitochondria in disease: changes in shapes and dynamics

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-04-01 DOI:10.1016/j.tibs.2024.01.011

Brenita C. Jenkins , Kit Neikirk , Prasanna Katti , Steven M. Claypool , Annet Kirabo , Melanie R. McReynolds , Antentor Hinton Jr.

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Abstract

Mitochondrial structure often determines the function of these highly dynamic, multifunctional, eukaryotic organelles, which are essential for maintaining cellular health. The dynamic nature of mitochondria is apparent in descriptions of different mitochondrial shapes [e.g., donuts, megamitochondria (MGs), and nanotunnels] and crista dynamics. This review explores the significance of dynamic alterations in mitochondrial morphology and regulators of mitochondrial and cristae shape. We focus on studies across tissue types and also describe new microscopy techniques for detecting mitochondrial morphologies both in vivo and in vitro that can improve understanding of mitochondrial structure. We highlight the potential therapeutic benefits of regulating mitochondrial morphology and discuss prospective avenues to restore mitochondrial bioenergetics to manage diseases related to mitochondrial dysfunction.

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疾病中的线粒体：形状和动态变化。

线粒体的结构往往决定了这些高度动态、多功能真核细胞器的功能，而线粒体对维持细胞健康至关重要。线粒体的动态特性在不同线粒体形状（如甜甜圈、巨线粒体（MG）和纳米隧道）和嵴动态的描述中显而易见。本综述探讨了线粒体形态动态变化的意义以及线粒体和嵴形态的调节因素。我们将重点放在跨组织类型的研究上，并介绍了用于检测体内和体外线粒体形态的新显微镜技术，这些技术可提高对线粒体结构的认识。我们强调了调节线粒体形态的潜在治疗效果，并讨论了恢复线粒体生物能以控制线粒体功能障碍相关疾病的前景。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.

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