Poly(vinyl alcohol) /Alginate nanofibrous mats containing Malva Sylvestris extract: Synthesis, characterization, in vitro and in vivo assessments for burn wound applications
{"title":"Poly(vinyl alcohol) /Alginate nanofibrous mats containing Malva Sylvestris extract: Synthesis, characterization, in vitro and in vivo assessments for burn wound applications","authors":"Ali Akbarpour , Mostafa Rahimnejad , Mona Sadeghi-Aghbash , Farideh Feizi","doi":"10.1016/j.ijpharm.2024.123928","DOIUrl":null,"url":null,"abstract":"<div><p>An important part of wound healing is providing effective wound care, coupled with preventing wound infection, which slows or disrupts healing. There are currently many herbal plants that have historical supernatural properties that show remarkable wound healing abilities. These herbal extracts have shown promising results when applied to electrospun nanofibrous mats platforms for wound healing. Accordingly, <em>Malva Sylvestris</em> extract (<em>MS</em>) was electrospun into polyvinyl alcohol/alginate nanofibrous mats (PVA/ALG). Field Emission Scanning Electron Microscopy (FESEM) demonstrated that the fiber diameter ranged from approximately 100–200 nm in nanofibrous mats, with a uniform appearance without beads. <em>MS</em> extract was detected in nanofibrous mats by Fourier Transform Infrared Spectroscopy (FTIR). A major benefit of incorporating <em>MS</em> extract into PVA/ALG nanofibrous mats is that their alterations have resulted in enhanced mechanical characteristics. The nanofibrous mats containing <em>MS</em> extracts showed significantly increased antibacterial efficacy against Gram-positive and Gram-negative bacteria. Based on the findings from in vivo experiments, the PVA/ALG/<em>MS</em>1 (M2) dressing demonstrated a wound closure rate of 93–94 % within 21 days of treatment in rats, indicating its significant potential for use as a wound dressing agent in the treatment of burn injuries. The combination of PVA, ALG, and <em>MS</em>1 in this nanofibrous mats exhibited beneficial properties, including biocompatibility, suitable mechanical strength, and the ability to promote cellular proliferation and angiogenesis, further validating its effectiveness as a wound healing dressing.</p></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378517324001625","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
An important part of wound healing is providing effective wound care, coupled with preventing wound infection, which slows or disrupts healing. There are currently many herbal plants that have historical supernatural properties that show remarkable wound healing abilities. These herbal extracts have shown promising results when applied to electrospun nanofibrous mats platforms for wound healing. Accordingly, Malva Sylvestris extract (MS) was electrospun into polyvinyl alcohol/alginate nanofibrous mats (PVA/ALG). Field Emission Scanning Electron Microscopy (FESEM) demonstrated that the fiber diameter ranged from approximately 100–200 nm in nanofibrous mats, with a uniform appearance without beads. MS extract was detected in nanofibrous mats by Fourier Transform Infrared Spectroscopy (FTIR). A major benefit of incorporating MS extract into PVA/ALG nanofibrous mats is that their alterations have resulted in enhanced mechanical characteristics. The nanofibrous mats containing MS extracts showed significantly increased antibacterial efficacy against Gram-positive and Gram-negative bacteria. Based on the findings from in vivo experiments, the PVA/ALG/MS1 (M2) dressing demonstrated a wound closure rate of 93–94 % within 21 days of treatment in rats, indicating its significant potential for use as a wound dressing agent in the treatment of burn injuries. The combination of PVA, ALG, and MS1 in this nanofibrous mats exhibited beneficial properties, including biocompatibility, suitable mechanical strength, and the ability to promote cellular proliferation and angiogenesis, further validating its effectiveness as a wound healing dressing.
期刊介绍:
The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.