Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine journal Pub Date : 2024-02-23 DOI:10.1507/endocrj.ej23-0525
Aika Miya, Akinobu Nakamura, Hiroshi Nomoto, Hiraku Kameda, Tatsuya Atsumi
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Abstract

The proinsulin-to-C-peptide (PI:C) ratio is an index applied during the early stage of pancreatic β-cell dysfunction. The aim of this study was to identify the characteristics associated with the PI:C ratio to discuss pancreatic β-cell dysfunction progression during the natural course of type 2 diabetes and its relationship with glycemic management. This multicenter, prospective observational study included 272 outpatients with type 2 diabetes. Continuous glucose monitoring was performed and fasting blood samples were collected and analyzed. We identified the clinical factors associated with the PI:C ratio by multiple regression analysis. The mean age of the cohort was 68.0 years, mean hemoglobin A1c 7.1% (54 mmol/mol), and mean body mass index 24.9 kg/m2. Multiple regression analysis showed that a prolonged time above the target glucose range (>180 mg/dL) and high body mass index contributed to a high PI:C ratio. However, no associations were found between the PI:C ratio and glucose variability indices. These findings suggested that the PI:C ratio is positively associated with a prolonged hyperglycemic time in type 2 diabetes, whereas its relationship with glucose variability remains unclear.

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2 型糖尿病患者的原胰岛素-C 肽比值与高血糖时间延长之间存在正相关关系
前胰岛素-C 肽(PI:C)比值是胰岛β细胞功能障碍早期阶段的一项指标。本研究旨在确定与 PI:C 比值相关的特征,以探讨 2 型糖尿病自然病程中胰岛 β 细胞功能障碍的进展及其与血糖管理的关系。这项多中心前瞻性观察研究纳入了 272 名 2 型糖尿病门诊患者。研究人员进行了连续血糖监测,并收集和分析了空腹血样。我们通过多元回归分析确定了与 PI:C 比值相关的临床因素。组群的平均年龄为 68.0 岁,平均血红蛋白 A1c 为 7.1% (54 mmol/mol),平均体重指数为 24.9 kg/m2。多元回归分析表明,超过目标血糖范围(180 毫克/分升)的时间过长和体重指数过高会导致 PI:C 比值过高。然而,PI:C 比值与血糖变异指数之间没有关联。这些研究结果表明,PI:C 比值与 2 型糖尿病患者的高血糖时间延长呈正相关,但其与血糖变异性的关系仍不明确。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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