Special Issue on Electrochemically-Driven Organic Synthesis

IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2024-02-22 DOI:10.1002/ijch.202400022
Prof. Dr. Lutz Ackermann
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Thus, Xu reviewed strategies that exploit ferrocene as redox catalyst, emphasizing the power towards catalyzed radical formation.<span><sup>3</sup></span> Likewise, Onomura summarized the potential of halogen mediators for environmentally-benign and at the same time efficient alcohol oxidations.<span><sup>4</sup></span> Jiao and Mei showed the power of paired electrolysis for organic reactions with ideal resource-economy,<span><sup>5</sup></span> while Cheng outlined the challenges and benefits of water as a particularly benign reaction medium.<span><sup>6</sup></span> Besides electrooxidative strategies, electroreductive transformations have garnered major recent attention. In this context, Weix summarized electrochemical nickel-catalyzed C−C bond formations through cross-electrophile coupling,<span><sup>7</sup></span> while Gosmini provided an overview on powerful transition metal-catalyzed electroreductive approachess for C−C bond formation.<span><sup>8</sup></span> On a different note, de Sarkar focused on electroreductive transformations involving C−C and C−O multiple bonds.<span><sup>9</sup></span> Novel innovative concepts in the realm of organic electrosynthesis, are presented in selected research articles highlighting exciting recent advances. Here, Ruan established an electrochemical cascade cyclization for a convenient access to 3-selenylindoles,<span><sup>10</sup></span> while Ackermann established C7-indole alkenylations based on rhodaelectrocatalysis.<span><sup>11</sup></span> The elegant design of an off/on switching enabled Kakiuchi to establish a one-pot cross-coupling/C−H bromination for bromoarylpyridines.<span><sup>12</sup></span> Finally, Fuchigami systematically compared the impact of the anode materials on the performance in diverse anodic transformations.<span><sup>13</sup></span></p><p>© WSS, Felix Wey</p><p>Overall, the great progress in organic electrochemistry is mirrored in this Special Issue by outstanding contributions of world-leading practitioners in the field from America, Europe, and Asia, reflecting the international importance of exploiting electricity for a sustainable future. 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Abstract

Molecular synthesis has gained considerable momentum through the impetus provided by electrochemically-enabled redox manipulation.1 Organic electrosynthesis and electrocatalysis bear a unique potential to substantially improve molecular chemistry and provide a wide range of innovative transformations. While a first electrochemically-driven organic synthesis dates back to Kolbe's decarboxylative homocoupling in 1848,2 organic electrosynthesis has remained largely underexplored. Particularly, recent years have witnessed a remarkable renaissance of electrochemically-enabled organic reactions. Pioneering contributions have during the past several years illustrated the unique opportunities that electrochemistry offers for the assembly of novel molecular structures, while improving the efficiency and sustainability of molecular synthesis. In this Special Issue, the Israelian Journal of Chemistry highlights the latest progress in this field.

Articles enclosed in this Special Issue cover overviews of important recent achievements in electrochemically driven organic synthesis as well as important original research articles on molecular organic electrosynthesis. Thus, Xu reviewed strategies that exploit ferrocene as redox catalyst, emphasizing the power towards catalyzed radical formation.3 Likewise, Onomura summarized the potential of halogen mediators for environmentally-benign and at the same time efficient alcohol oxidations.4 Jiao and Mei showed the power of paired electrolysis for organic reactions with ideal resource-economy,5 while Cheng outlined the challenges and benefits of water as a particularly benign reaction medium.6 Besides electrooxidative strategies, electroreductive transformations have garnered major recent attention. In this context, Weix summarized electrochemical nickel-catalyzed C−C bond formations through cross-electrophile coupling,7 while Gosmini provided an overview on powerful transition metal-catalyzed electroreductive approachess for C−C bond formation.8 On a different note, de Sarkar focused on electroreductive transformations involving C−C and C−O multiple bonds.9 Novel innovative concepts in the realm of organic electrosynthesis, are presented in selected research articles highlighting exciting recent advances. Here, Ruan established an electrochemical cascade cyclization for a convenient access to 3-selenylindoles,10 while Ackermann established C7-indole alkenylations based on rhodaelectrocatalysis.11 The elegant design of an off/on switching enabled Kakiuchi to establish a one-pot cross-coupling/C−H bromination for bromoarylpyridines.12 Finally, Fuchigami systematically compared the impact of the anode materials on the performance in diverse anodic transformations.13

© WSS, Felix Wey

Overall, the great progress in organic electrochemistry is mirrored in this Special Issue by outstanding contributions of world-leading practitioners in the field from America, Europe, and Asia, reflecting the international importance of exploiting electricity for a sustainable future. Electrochemical organic synthesis has the potential to directly contribute to numerous Sustainable Development Goals of the United Nations,14 including the goals “good health and well-being, “affordable and clean energy”, “industry, innovation and infrastructure”, “responsible consumption and production”, and “climate action”. At the same time the unifying impact of electrochemistry addresses all of the twelve principles of green chemistry.15 Overall, electrochemical molecular synthesis has been recognized as uniquely powerful platform for organic chemists. Given the outstanding innovation potential of organic electrochemistry for the sustainable assembly of organic molecules, various exciting advances are expected in this rapidly evolving research arena.

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电化学驱动的有机合成特刊
1 有机电合成和电催化在大幅改进分子化学和提供广泛的创新转化方面具有独特的潜力。虽然最早的电化学驱动有机合成可追溯到 1848 年 Kolbe 的脱羧同偶联反应2 ,但有机电合成在很大程度上仍未得到充分探索。特别是近年来,电化学驱动的有机反应出现了显著的复兴。过去几年中,一些开创性的研究成果表明,电化学为组装新型分子结构提供了独特的机会,同时提高了分子合成的效率和可持续性。在本特刊中,《以色列化学杂志》重点介绍了这一领域的最新进展。本特刊收录的文章包括电化学驱动有机合成领域最新重要成就的概述,以及有关分子有机电合成的重要原创研究文章。因此,Xu 综述了利用二茂铁作为氧化还原催化剂的策略,强调了催化自由基形成的威力。3 同样,Onomura 总结了卤素介质在环境无害同时高效的醇氧化中的潜力。在这方面,Weix 总结了通过交叉亲电偶联的电化学镍催化 C-C 键形成7,而 Gosmini 则概述了强大的过渡金属催化 C-C 键形成的电还原方法8。其中,Ruan 建立了一种电化学级联环化方法,可方便地获得 3-硒基吲哚10,而 Ackermann 则建立了基于 rhodaelectrocatalysis 的 C7-indole 烯化反应11。最后,Fuchigami 系统地比较了阳极材料对各种阳极转化性能的影响。13 © WSS, Felix Wey总之,本特刊反映了有机电化学领域的巨大进步,来自美国、欧洲和亚洲的该领域世界领先的从业人员做出了杰出贡献,反映了利用电力实现可持续未来的国际重要性。电化学有机合成具有直接促进实现联合国众多可持续发展目标14 的潜力,包括 "良好的健康和福祉"、"负担得起的清洁能源"、"工业、创新和基础设施"、"负责任的消费和生产 "以及 "气候行动 "等目标。同时,电化学的统一影响涉及到绿色化学的所有十二项原则15。总体而言,电化学分子合成已被公认为有机化学家独一无二的强大平台。鉴于有机电化学在有机分子的可持续组装方面具有突出的创新潜力,预计这一快速发展的研究领 域将取得各种令人振奋的进展。
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来源期刊
Israel Journal of Chemistry
Israel Journal of Chemistry 化学-化学综合
CiteScore
6.20
自引率
0.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
期刊最新文献
Cover Picture: (Isr. J. Chem. 8-9/2024) Special Issue on RNA-Based Catalysts that Revolutionized the Discovery of Bioactive Peptides Hexagonal and Trigonal Quasiperiodic Tilings Breaking the Degeneracy of Sense Codons – How Far Can We Go? Cover Picture: (Isr. J. Chem. 6-7/2024)
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