Retinoid Treatment for Oral Leukoplakia: Current Evidence and Future Development

IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY Journal of Clinical Pharmacy and Therapeutics Pub Date : 2024-02-20 DOI:10.1155/2024/6616979
Yuting Hu, Ying Wang, Ying Li, Xin Zeng, Jing Li, Yu Zhou, Qianming Chen
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Abstract

Oral leukoplakia (OLK) is one of the most common oral potentially malignant disorders (OPMDs). Preventing malignant transformation is the main purpose of OLK treatment. The treatment approaches of OLK include surgery, chemotherapy, and other therapies, such as photodynamic therapy and CO2 laser. The application of genomic variation-based chemotherapy in OLK deserves further exploration. As chemopreventive drugs, drug resistance and disease recurrence have limited their use in OLK. In this review, we concentrate on the retinoid treatment for OLK, summarizing the current status of retinoids in the treatment of OLK, the mechanism of retinoid action, and the mechanisms of resistance to retinoid therapy, and we highlight the strategies to improve retinoid efficacy in the treatment of OLK, such as the combination of retinoids and epigenetic regulators or metabolism-blocking agents, new synthetic retinoids, and new drug delivery systems of retinoids, providing new methods for the successful clinical application of retinoids in the treatment of OLK.

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口腔白斑病的维甲酸治疗:当前证据与未来发展
口腔白斑病(OLK)是最常见的口腔潜在恶性疾病(OPMD)之一。防止恶变是口腔白斑病治疗的主要目的。OLK的治疗方法包括手术、化疗和其他疗法,如光动力疗法和二氧化碳激光。基于基因组变异的化疗在 OLK 中的应用值得进一步探讨。作为化学预防药物,耐药性和疾病复发限制了它们在 OLK 中的应用。在这篇综述中,我们集中讨论了维甲酸治疗OLK的问题,总结了维甲酸治疗OLK的现状、维甲酸的作用机制以及维甲酸治疗的耐药机制,并着重介绍了提高维甲酸治疗OLK疗效的策略,如维甲酸与表观遗传调节剂或代谢阻断剂的联合应用、新合成的维甲酸、维甲酸的新给药系统等,为维甲酸在临床上成功应用于OLK的治疗提供了新的方法。
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来源期刊
CiteScore
4.10
自引率
5.00%
发文量
226
审稿时长
6 months
期刊介绍: The Journal of Clinical Pharmacy and Therapeutics provides a forum for clinicians, pharmacists and pharmacologists to explore and report on issues of common interest. Reports and commentaries on current issues in medical and pharmaceutical practice are encouraged. Papers on evidence-based clinical practice and multidisciplinary collaborative work are particularly welcome. Regular sections in the journal include: editorials, commentaries, reviews (including systematic overviews and meta-analyses), original research and reports, and book reviews. Its scope embraces all aspects of clinical drug development and therapeutics, including: Rational therapeutics Evidence-based practice Safety, cost-effectiveness and clinical efficacy of drugs Drug interactions Clinical impact of drug formulations Pharmacogenetics Personalised, stratified and translational medicine Clinical pharmacokinetics.
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