Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer†

IF 5.6 2区医学 Q1 ONCOLOGY The Journal of Pathology Pub Date : 2024-02-25 DOI:10.1002/path.6268

Derya Bakırdöğen, Kıvanç Görgülü, Hana Algül

引用次数: 0

Abstract

Advances in the digital pathology field have facilitated the characterization of histology samples for both clinical and preclinical research. However, uncovering subtle correlations between bioimaging, clinical and molecular parameters requires extensive statistical analysis. As a user-friendly software, Hourglass, simplifies multiparametric dataset analysis through intuitive data visualization and statistical tools. Systemic analysis of interleukin-6 (IL-6)/pStat3 signaling pathway through Hourglass revealed differences in regional immune cell composition within tumors. Moreover, these regional disparities were partially mediated by sex. Overall, Hourglass simplifies information extraction from complex datasets, resolving overlooked regional and global spatial tumor differences. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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沙漏，胰腺癌全球和区域异质性的指南针†。

数字病理学领域的进步促进了临床和临床前研究中组织学样本的特征描述。然而，发现生物成像、临床和分子参数之间的微妙关联需要大量的统计分析。作为一款用户友好型软件，Hourglass 通过直观的数据可视化和统计工具简化了多参数数据集分析。通过 Hourglass 对白细胞介素-6（IL-6）/pStat3 信号通路的系统分析，发现了肿瘤内区域免疫细胞组成的差异。此外，这些区域差异部分是由性别介导的。总之，Hourglass 简化了复杂数据集的信息提取，解决了被忽视的区域和全球肿瘤空间差异问题。© 2024 作者。病理学杂志》由 John Wiley & Sons Ltd 代表大不列颠及爱尔兰病理学会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Pathology 医学-病理学

CiteScore

14.10

自引率

1.40%

发文量

144

审稿时长

3-8 weeks

期刊介绍： The Journal of Pathology aims to serve as a translational bridge between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The main interests of the Journal lie in publishing studies that further our understanding the pathophysiological and pathogenetic mechanisms of human disease. The Journal of Pathology welcomes investigative studies on human tissues, in vitro and in vivo experimental studies, and investigations based on animal models with a clear relevance to human disease, including transgenic systems. As well as original research papers, the Journal seeks to provide rapid publication in a variety of other formats, including editorials, review articles, commentaries and perspectives and other features, both contributed and solicited.