{"title":"ITAM-based receptors in natural killer cells","authors":"Oscar A. Aguilar, Lam-Kiu Fong, Lewis L. Lanier","doi":"10.1111/imr.13313","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by demonstrating that they can also gain adaptive features. This has been observed in both humans and mice during infection with cytomegalovirus (CMV). The generation of adaptive NK cells requires antigen-specific recognition of virally infected cells through stimulatory NK receptors. These receptors lack the ability to signal on their own and rather rely on adaptor molecules that contain ITAMs for driving signals. Here, we highlight our understanding of how these receptors influence the production of adaptive NK cells and propose areas in the field that merit further investigation.</p>\n </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"323 1","pages":"40-53"},"PeriodicalIF":7.5000,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological Reviews","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/imr.13313","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by demonstrating that they can also gain adaptive features. This has been observed in both humans and mice during infection with cytomegalovirus (CMV). The generation of adaptive NK cells requires antigen-specific recognition of virally infected cells through stimulatory NK receptors. These receptors lack the ability to signal on their own and rather rely on adaptor molecules that contain ITAMs for driving signals. Here, we highlight our understanding of how these receptors influence the production of adaptive NK cells and propose areas in the field that merit further investigation.
长期以来,人们一直认为只有适应性免疫系统的细胞才有能力获得寿命延长和次级反应增强等特征。自然杀伤(NK)细胞对这一观点提出了挑战,证明它们也能获得适应性特征。人类和小鼠在感染巨细胞病毒(CMV)时都观察到了这一现象。适应性 NK 细胞的产生需要通过刺激性 NK 受体对病毒感染细胞进行抗原特异性识别。这些受体自身缺乏发出信号的能力,而是依赖含有 ITAMs 的适配体分子来驱动信号。在此,我们将重点介绍我们对这些受体如何影响适应性 NK 细胞产生的理解,并提出该领域值得进一步研究的领域。
期刊介绍:
Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system.
The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.