Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection.

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI:10.1007/s11906-023-01292-y

Annelene Govindsamy, Shoohana Singh, Thajasvarie Naicker

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Abstract

Purpose of review: The primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection.

Recent findings: There is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism showed no significant association with the development of pregnancy-induced hypertension. There are conflicting findings when determining the relationship between ethnicity and the predisposition of preeclampsia and hypertension in relation to the discussed RAAS-associated SNPs. To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene are more prominent in HIV-infected PE compared to normotensive pregnant HIV-infected women.

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RAAS 相关 SNPs 的遗传评估：感染 HIV 的先兆子痫妇女的 REN (rs16853055)、AGT (rs3789678) 和 ACE (rs4305)。

综述目的：这篇综述文章的主要目的是确定三个 RAAS 相关 SNPs（Renin-rs16853055、AGT-rs3789678 和 ACE-rs4305）是否与子痫前期高血压的发生有遗传联系。次要目标是确定这些 SNPs 与 HIV 感染之间是否存在联系：与上述 SNP 和子痫前期有关的研究结果很少。目前还没有关于 rs16853055 肾素多态性的最新研究结果。rs3789678血管紧张素原多态性与妊娠高血压有显著相关性。rs4305 ACE 多态性与妊娠诱发高血压的发生无明显关联。在确定种族与先兆子痫和高血压易感性之间的关系时，与所讨论的 RAAS 相关 SNPs 有关的研究结果相互矛盾。迄今为止，南非研究 RAAS 相关 SNP 与合并艾滋病毒的子痫前期妇女之间的关系时发现，与血压正常的艾滋病毒感染孕妇相比，AGT 基因的某些等位基因在艾滋病毒感染的 PE 中更为突出。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.