Independent Association between Cognitive Frailty and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY Gerontology Pub Date : 2024-01-01 Epub Date: 2024-02-26 DOI:10.1159/000536653

Shoma Akaida, Yoshiaki Taniguchi, Yuki Nakai, Yuto Kiuchi, Mana Tateishi, Daijo Shiratsuchi, Toshihiro Takenaka, Takuro Kubozono, Mitsuru Ohishi, Hyuma Makizako

{"title":"Independent Association between Cognitive Frailty and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults.","authors":"Shoma Akaida, Yoshiaki Taniguchi, Yuki Nakai, Yuto Kiuchi, Mana Tateishi, Daijo Shiratsuchi, Toshihiro Takenaka, Takuro Kubozono, Mitsuru Ohishi, Hyuma Makizako","doi":"10.1159/000536653","DOIUrl":null,"url":null,"abstract":"Introduction: Although arterial stiffness has been suggested to be associated with poor physical function and mild cognitive impairment (MCI), its association with cognitive frailty (CF), a comorbidity of both, is unclear. This study aims to examine the association between CF and arterial stiffness in community-dwelling older adults.Methods: A cross-sectional analysis of 511 community-dwelling older adults aged 65 years or older (mean age 73.6 ± 6.2 years, 63.6% women), who participated in a community cohort study (Tarumizu Study, 2019), was conducted. Poor physical function was defined as either slowness (walking speed <1.0 m/s) or weakness (grip strength <28 kg for men and <18 kg for women). MCI was defined by the National Center for Geriatrics and Gerontology Functional Assessment Tool as a decline of at least 1.5 standard deviation from age- and education-adjusted baseline values in any one of the four cognitive domains (memory, attention, executive, and information processing). CF was defined as the combination of poor physical function and MCI. Arterial stiffness was measured using the Cardio-Ankle Vascular Index (CAVI), and the average of the left and right sides (mean CAVI) was used.Results: Multinomial logistic regression analysis adjusted for covariates was performed with the four groups of robust, poor physical function, MCI, and CF as dependent variables and mean CAVI as an independent variable. Using the robust group as reference, the poor physical function and MCI groups showed no significant relationship with the mean CAVI. The mean CAVI was significantly higher in the CF group (odds ratio 1.62, 95% confidence interval: 1.14-2.29).Conclusion: A significant association was found between CF and the higher CAVI (progression of arterial stiffness). Careful observation and control of CAVI, which is also an indicator of arterial stiffness, may be a potential target for preventive interventions for CF.","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000536653","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Although arterial stiffness has been suggested to be associated with poor physical function and mild cognitive impairment (MCI), its association with cognitive frailty (CF), a comorbidity of both, is unclear. This study aims to examine the association between CF and arterial stiffness in community-dwelling older adults.

Methods: A cross-sectional analysis of 511 community-dwelling older adults aged 65 years or older (mean age 73.6 ± 6.2 years, 63.6% women), who participated in a community cohort study (Tarumizu Study, 2019), was conducted. Poor physical function was defined as either slowness (walking speed <1.0 m/s) or weakness (grip strength <28 kg for men and <18 kg for women). MCI was defined by the National Center for Geriatrics and Gerontology Functional Assessment Tool as a decline of at least 1.5 standard deviation from age- and education-adjusted baseline values in any one of the four cognitive domains (memory, attention, executive, and information processing). CF was defined as the combination of poor physical function and MCI. Arterial stiffness was measured using the Cardio-Ankle Vascular Index (CAVI), and the average of the left and right sides (mean CAVI) was used.

Results: Multinomial logistic regression analysis adjusted for covariates was performed with the four groups of robust, poor physical function, MCI, and CF as dependent variables and mean CAVI as an independent variable. Using the robust group as reference, the poor physical function and MCI groups showed no significant relationship with the mean CAVI. The mean CAVI was significantly higher in the CF group (odds ratio 1.62, 95% confidence interval: 1.14-2.29).

Conclusion: A significant association was found between CF and the higher CAVI (progression of arterial stiffness). Careful observation and control of CAVI, which is also an indicator of arterial stiffness, may be a potential target for preventive interventions for CF.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

在社区居住的老年人中，认知能力衰弱与心-踝血管指数之间存在独立关联。

导言：尽管动脉僵化被认为与身体功能不佳和轻度认知障碍（MCI）有关，但它与认知虚弱（CF）（两者的合并症）之间的关系尚不清楚。本研究旨在探讨社区老年人的认知虚弱（CF）与动脉僵化之间的关系。方法对参加社区队列研究（Tarumizu Study，2019 年）的 511 名 65 岁或以上的社区老年人（平均年龄为 73.6 ± 6.2 岁，63.6% 为女性）进行横断面分析。身体功能不佳的定义是行动迟缓（步行速度< 1.0 米/秒）或无力（男性握力< 28 千克，女性握力< 18 千克）。根据美国国家老年医学和老年学中心功能评估工具的定义，MCI 是指在四个认知领域（记忆、注意力、执行力和信息处理）中的任何一个领域，与年龄和教育调整后的基线值相比，下降至少 1.5 个标准差。CF 被定义为身体功能差和 MCI 的组合。动脉僵硬度采用心-踝血管指数（CAVI）进行测量，并采用左右两侧的平均值（CAVI 平均值）。结果以健壮组、身体功能差组、MCI 组和 CF 组四个组别为因变量，以 CAVI 平均值为自变量，进行了调整协变量的多项式逻辑回归分析。以体格健壮组为参照，体能较差组和 MCI 组与平均 CAVI 无明显关系。CF 组的平均 CAVI 明显较高（几率比 1.62，95% 置信区间 1.14-2.29）。结论发现 CF 与 CAVI 升高（动脉僵化进展）之间存在明显关联。CAVI也是动脉僵化的一个指标，仔细观察和控制CAVI可能是CF预防干预的一个潜在目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.