Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma in adolescents.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International Archives of Occupational and Environmental Health Pub Date : 2024-04-01 Epub Date: 2024-02-27 DOI:10.1007/s00420-024-02047-1

Yi-Fan Wang, Li Li, Xu Wang, Ya-Nan Yun, Xue-Lin Wang, En-Yang He, Ming-Kun Song, Xue-Hong Xia, Ying-Xue Zou

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Abstract

Background: Previous epidemiological studies about the relationship between per- and polyfluoroalkyl substances (PFAS) concentrations and adolescent asthma have typically examined single PFAS, without considering the mixtures effects of PFAS.

Methods: Using data from the 2013-2018 National Health and Nutrition Examination Survey (NHANES), 886 adolescents aged 12-19 years were included in this study. We explored the association between PFAS mixture concentrations and adolescent asthma using weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models, respectively.

Results: After adjusting for confounders, the results of the WQS regression and BKMR models were consistent, with mixed exposure to the five PFAS not significantly associated with asthma in all adolescents. The association remained nonsignificant in the subgroup analysis by sex.

Conclusions: Our study demonstrated no significant association between mixed exposure to PFAS and adolescent asthma, and more large cohort studies are needed to confirm this in the future.

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全氟和多氟烷基物质混合物与青少年哮喘的环境接触。

背景：以往有关全氟烷基和多氟烷基物质（PFAS）浓度与青少年哮喘之间关系的流行病学研究通常只研究单一的全氟烷基和多氟烷基物质，而不考虑全氟烷基和多氟烷基物质的混合物效应：本研究利用 2013-2018 年美国国家健康与营养调查（NHANES）的数据，纳入了 886 名 12-19 岁的青少年。我们分别使用加权量化和（WQS）回归模型和贝叶斯核机器回归（BKMR）模型探讨了PFAS混合物浓度与青少年哮喘之间的关系：结果：在对混杂因素进行调整后，WQS 回归和 BKMR 模型的结果一致，在所有青少年中，五种全氟辛烷磺酸的混合暴露与哮喘的关系不大。在按性别进行的亚组分析中，这种关系仍然不显著：我们的研究表明，混合接触全氟辛烷磺酸与青少年哮喘之间没有明显的关联，今后需要更多的大型队列研究来证实这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.