Cutting-edge skin ageing research on tissue stem cell.

IF 2.1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of biochemistry Pub Date : 2024-09-30 DOI:10.1093/jb/mvae022
Ryo Ichijo
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Abstract

In developed economies, the growing number of older individuals is a pressing issue. As a result, research progress into ageing has emphasized the significance of staying healthy in one's later years. Stem cells have a fundamental role to play in fostering diverse cell types and necessary processes for tissue repair and regeneration. Stem cells experience the effects of ageing over time, which is caused by their functional deterioration. Changes to stem cells, their niches and signals from other tissues they interact with are crucial factors in the ageing of stem cells. Progress in single-cell RNA sequencing (scRNA-seq) technology has greatly advanced stem cell research. This review examines the mechanisms of stem cell ageing, its impact on health and investigates the potential of stem cell therapy, with a special emphasis on the skin.

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关于组织干细胞的尖端皮肤老化研究。
在发达经济体中,老年人数量的不断增长是一个紧迫的问题。因此,老龄化研究的进展强调了晚年保持健康的重要性。干细胞在培育多种细胞类型以及组织修复和再生的必要过程中发挥着重要作用。随着时间的推移,干细胞会受到老化的影响,这是由干细胞的功能退化引起的。干细胞及其龛位的变化,以及与之相互作用的其他组织发出的信号,是干细胞老化的关键因素。单细胞RNA测序(scRNA-seq)技术的进步极大地推动了干细胞研究。这篇综述探讨了干细胞老化的机制及其对健康的影响,并研究了干细胞疗法的潜力,特别侧重于皮肤。
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来源期刊
Journal of biochemistry
Journal of biochemistry 生物-生化与分子生物学
CiteScore
4.80
自引率
3.70%
发文量
101
审稿时长
4-8 weeks
期刊介绍: The Journal of Biochemistry founded in 1922 publishes the results of original research in the fields of Biochemistry, Molecular Biology, Cell, and Biotechnology written in English in the form of Regular Papers or Rapid Communications. A Rapid Communication is not a preliminary note, but it is, though brief, a complete and final publication. The materials described in Rapid Communications should not be included in a later paper. The Journal also publishes short reviews (JB Review) and papers solicited by the Editorial Board.
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