[THE EFFICACY OF BRONCHIAL THERMOPLASTY IN LONG-TERM MAINTENANCE OF ADULT PATIENTS WITH MODERATE TO SEVERE ASTHMA].

Q4 Medicine Japanese Journal of Allergology Pub Date : 2024-01-01 DOI:10.15036/arerugi.73.40

Takahiro Matsuyama, Jun Tanaka, Kazuya Tone, Kaoruko Shimizu, Takako Nakano, Koichiro Takahashi

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Abstract

Background and aims: Bronchial thermoplasty (BT) is a bronchoscopic treatment for adult patients with moderate to severe asthma. A systematic review was conducted to examine the efficacy of this treatment.

Methods: Randomized controlled comparing BT to a control in adult patients with moderate to severe asthma were added to the previously conducted systematic review. Literature published prior to July 2022 was selected.

Results: Four trials were included in this study. BT resulted in significant improvement in quality of life. However, no significant difference in asthma control was observed. Moreover, the incidence of severe adverse events during the treatment period was increased by BT. Furthermore, BT did not improve lung function, increase withdrawal from oral corticosteroids, reduce frequency of rescue medication usage, or increase the number of symptom-free days.

Conclusion: From a risk-benefit perspective, there is insufficient evidence to support a recommendation of BT in adult patients with moderate to severe asthma.

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[支气管热成形术对中重度哮喘成年患者的长期疗效]。

背景和目的：支气管热成形术（BT）是一种针对中重度哮喘成年患者的支气管镜治疗方法。为研究该疗法的疗效，我们进行了一项系统性综述：方法：在之前进行的系统综述基础上，增加了对中重度哮喘成年患者进行 BT 与对照比较的随机对照研究。选择了 2022 年 7 月之前发表的文献：本研究纳入了四项试验。BT 显著改善了患者的生活质量。然而，在哮喘控制方面没有观察到明显差异。此外，BT 还增加了治疗期间严重不良事件的发生率。此外，BT 并未改善肺功能、增加口服皮质类固醇的停药次数、减少抢救药物的使用频率或增加无症状天数：结论：从风险收益的角度来看，没有足够的证据支持对中重度哮喘成年患者推荐使用 BT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Allergology Medicine-Immunology and Allergy

CiteScore

0.30

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0.00%

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期刊介绍： The Japanese Society of Allergology is made up of medical researchers and clinical physicians who share an involvement in the study of allergies and clinical immunology. Clinical subspecialties include such allergies and immune-response disorders as bronchial asthma, hypersensitivity pneumonitis, collagen disease, allergic rhinitis, pollenosis, hives, atopic dermatitis, and immunodeficiency. However, there are many patients afflicted by other allergies as well. The Society considers all such patients and disorders within its purview.

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