Obesity and risk of depressive disorder in children and adolescents: A meta-analysis of observational studies

IF 1.8 4区医学 Q2 PEDIATRICS Child Care Health and Development Pub Date : 2024-02-26 DOI:10.1111/cch.13237

Yaobing Chen, Jinli Zhang, Lijun Yuan, Huifang Hu, Tianze Li, Yang Zhao, Yuying Wu, Mengmeng Wang, Weifeng Huo, Yajuan Gao, Yamin Ke, Longkang Wang, Wenkai Zhang, Xueru Fu, Xi Li, Fulan Hu, Ming Zhang, Liang Sun, Dongsheng Hu

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Abstract

Purpose

This meta-analysis evaluated the relationship between overweight/obesity and depressive disorders in children and adolescents.

Methods

We examined the databases of PubMed, Embase and Web of Science for pertinent observational studies released up until 20 February 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) of obesity and overweight with depressive disorder were calculated by means of random-effects models. The Newcastle-Ottawa Quality Assessment Scale and Agency for Healthcare Research and Quality scale were adopted to evaluate the study quality.

Results

Finally, for this meta-analysis, we evaluated 22 observational publications covering 175 135 participants (5 cohort study articles, 1 case–control study article and 16 cross-sectional study articles). A significant positive association was found between obesity and the risk of depression (RR 1.32, 95% CI 1.09–1.60, I² = 79.90%, P_{heterogeneity} < 0.001) and in the association between obesity and depressive symptoms (RR 1.16, 95% CI: 1.00–1.35, I² = 25.0%, P_{heterogeneity} = 0.247). On sensitivity analysis, the pooled RRs remained robust. Subgroup analysis indicated that obese children and teenagers in western countries were more prone to depression.

Conclusion

Evidence from this meta-analysis, based on observational studies, supported the idea that obese children and adolescents are more likely to experience depression and depressive symptoms.

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肥胖与儿童和青少年患抑郁症的风险：观察性研究的荟萃分析。

目的：这项荟萃分析评估了儿童和青少年超重/肥胖与抑郁障碍之间的关系：我们检索了 PubMed、Embase 和 Web of Science 数据库中截至 2022 年 2 月 20 日发布的相关观察性研究。通过随机效应模型计算了肥胖和超重与抑郁障碍的汇总相对风险（RRs）和95%置信区间（CIs）。采用纽卡斯尔-渥太华质量评估量表和美国医疗保健研究与质量机构量表评估研究质量：最后，在这项荟萃分析中，我们评估了 22 篇观察性出版物，涉及 175 135 名参与者（5 篇队列研究文章、1 篇病例对照研究文章和 16 篇横断面研究文章）。研究发现，肥胖与抑郁风险之间存在明显的正相关关系（RR 1.32，95% CI 1.09-1.60，I2 = 79.90%，Pheterogeneity 2 = 25.0%，Pheterogeneity = 0.247）。在敏感性分析中，汇总的RRs仍然稳健。亚组分析表明，西方国家的肥胖儿童和青少年更容易患抑郁症：这项基于观察性研究的荟萃分析提供的证据支持了肥胖儿童和青少年更容易患抑郁症和抑郁症状的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Child Care Health and Development 医学-小儿科

CiteScore

3.40

自引率

5.30%

发文量

136

审稿时长

4-8 weeks

期刊介绍： Child: care, health and development is an international, peer-reviewed journal which publishes papers dealing with all aspects of the health and development of children and young people. We aim to attract quantitative and qualitative research papers relevant to people from all disciplines working in child health. We welcome studies which examine the effects of social and environmental factors on health and development as well as those dealing with clinical issues, the organization of services and health policy. We particularly encourage the submission of studies related to those who are disadvantaged by physical, developmental, emotional and social problems. The journal also aims to collate important research findings and to provide a forum for discussion of global child health issues.