Phytostilbenes in lymphoma: Focuses on the mechanistic and clinical prospects of resveratrol, pterostilbene, piceatannol, and pinosylvin

IF 2.1 4区医学 Q3 HEMATOLOGY Leukemia research Pub Date : 2024-03-01 DOI:10.1016/j.leukres.2024.107464

Pouya Goleij , Pantea Majma Sanaye , Mehregan Babamohamadi , Mohammad Amin Khazeei Tabari , Roshanak Amirian , Aryan Rezaee , Hamed Mirzaei , Alan Prem Kumar , Gautam Sethi , Sarvin Sadreddini , Philippe Jeandet , Haroon Khan

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Abstract

Lymphoma is a cancer affecting the lymphatic system that fights infections and diseases. In addition to surgery, radiotherapy, and chemotherapy, novel approaches have recently been investigated, such as phytostilbenes in treating lymphoma. Phytostilbenes are natural compounds present in various plants and have been shown to have different therapeutic effects, including anticancer properties. Resveratrol is a main phytostilbene with various derivates followed by pterostilbene and piceatannol. Studies have revealed that phytostilbenes can suppress the growth and proliferation of lymphoma cells by inducing apoptosis and inhibiting specific enzyme activity in cancer cell survival. The compounds also have antiinflammatory effects contributing to reducing lymphoma-associated inflammation. Additionally, phytostilbenes have been shown to increase the immune system's ability to fight cancer cells by activating immune cells (T-cells and natural killer cells). This review investigates the potential therapeutic effects of phytostilbenes, including resveratrol, pterostilbene, piceatannol, and pinosylvin, against lymphoma.

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淋巴瘤中的植物芪：聚焦白藜芦醇、紫檀芪、皮杉醇和红松素的机理和临床前景

淋巴瘤是一种影响淋巴系统的癌症，淋巴系统能抵抗感染和疾病。除了手术、放疗和化疗外，最近还研究了一些新方法，如治疗淋巴瘤的植物芪。植物芪是存在于各种植物中的天然化合物，已被证明具有不同的治疗效果，包括抗癌特性。白藜芦醇是一种主要的植物甾二烯类化合物，其衍生物多种多样，其次是紫檀芪和紫杉醇。研究发现，植物甾二烯类化合物可通过诱导细胞凋亡和抑制癌细胞存活过程中特定酶的活性来抑制淋巴瘤细胞的生长和增殖。这些化合物还具有抗炎作用，有助于减轻淋巴瘤相关炎症。此外，植物芪还能通过激活免疫细胞（T 细胞和自然杀伤细胞）来提高免疫系统对抗癌细胞的能力。本综述研究了植物甾二烯类化合物（包括白藜芦醇、紫檀芪、紫杉醇和松萝素）对淋巴瘤的潜在治疗作用。

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来源期刊

Leukemia research 医学-血液学

CiteScore

4.00

自引率

3.70%

发文量

259

审稿时长

1 months

期刊介绍： Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and applied clinical research in hematological malignancies. The editors encourage the submission of articles relevant to hematological malignancies. The Journal scope includes reporting studies of cellular and molecular biology, genetics, immunology, epidemiology, clinical evaluation, and therapy of these diseases.