Diagnosis of Lennox-Gastaut syndrome and strategies for early recognition.

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Expert Review of Neurotherapeutics Pub Date : 2024-04-01 Epub Date: 2024-02-28 DOI:10.1080/14737175.2024.2323568
Suresh Pujar, J Helen Cross
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Abstract

Introduction: Lennox Gastaut syndrome (LGS) as an electroclinical diagnosis has been utilized as a clinical entity for more than 70 years. However, with the recognition of other distinct electroclinical epilepsy syndromes, no consistent single etiology, and the variability of criteria used in clinical trials, the clinical utility of such a diagnosis has been questioned. Recently, the International League Against Epilepsy for the first time defined diagnostic criteria for epilepsy syndromes, thereby allowing consistent language and inclusion criteria to be utilized.

Areas covered: Recent diagnostic criteria for syndrome diagnosis are explored as defined by the International League Against Epilepsy, with further literature reviewed to highlight relevant features, and differential diagnosis explored.

Expert opinion: Developmental and Epileptic Encephalopathy (DEE) is an overall term that may be descriptive of many different epilepsies, most of early onset, whether electroclinically or etiologically defined, of which LGS is one. Although we have moved forward in defining an increasing number of etiologically specific syndromes, this to date remains a minority of the DEEs. Although there is progress with precision medicine targeted at specific causes, the term LGS still remains useful as a diagnosis in defining treatment options, as well as overall prognosis.

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Lennox-Gastaut 综合征的诊断和早期识别策略。
导言:伦诺克斯-加斯托综合征(Lennox Gastaut syndrome,LGS)作为一种临床电临床诊断已使用了 70 多年。然而,随着人们认识到其他不同的癫痫电临床综合征,没有一致的单一病因,以及临床试验中使用的标准的多变性,这种诊断的临床实用性受到了质疑。最近,国际抗癫痫联盟首次定义了癫痫综合征的诊断标准,从而可以使用一致的语言和纳入标准:探讨国际抗癫痫联盟最新定义的综合征诊断标准,进一步回顾文献以突出相关特征,并探讨鉴别诊断:发育性和癫痫性脑病(DEE)是一个总称,可描述多种不同的癫痫,多数为早发性癫痫,无论是电clinically还是病因学定义的癫痫,LGS是其中之一。尽管我们已经定义了越来越多的病因特异性综合征,但迄今为止,这些综合征在 DEEs 中仍占少数。虽然针对特定病因的精准医疗取得了进展,但 LGS 作为一种诊断方法,在确定治疗方案和总体预后方面仍然非常有用。
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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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