Efficacy of a combination of esafoxolaner, eprinomectin and praziquantel (NexGard® Combo) against Thelazia callipaeda in naturally infected cats.

IF 2.3 2区 医学 Q2 PARASITOLOGY Parasite Pub Date : 2024-01-01 Epub Date: 2024-02-28 DOI:10.1051/parasite/2024008
Angela Di Cesare, Stefania Zanet, Donato Traversa, Mariasole Colombo, Eric Tielemans, Frederic Beugnet, Ezio Ferroglio
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Abstract

This clinical study assessed the efficacy of a topical combination of esafoxolaner, eprinomectin and praziquantel (NexGard® Combo) in treating cats naturally infected with the eyeworm Thelazia callipaeda (Nematoda, Thelaziidae). On Study Day (SD) 0, sixteen client-owned cats with eyeworm infection were allocated to an untreated control group (G1, 8 cats) or to a NexGard® Combo treated group (G2, 8 cats) and subjected to ocular examination. Cats in G2 received the treatment as per label recommendations. On SD 7 and 14 (±1), cats were examined for the presence of eyeworms and clinical signs. On SD 14, eyeworms were collected and counted. On SD 7 and 14, all cats in G1 were still infected with eyeworms, while G2 cats were free from eyeworms on SD 7 and 14, demonstrating 100% efficacy (p < 0.0001). All collected eyeworms were morphologically and molecularly confirmed to be T. callipaeda. On SD 0, fifteen out of the sixteen cats (7 in G1 and 8 in G2) displayed inflammatory ocular signs. On SD 7, all eight untreated cats and seven treated cats displayed inflammatory ocular signs. On SD 14, five out of eight G2 treated cats had recovered, while the eight untreated cats still displayed inflammatory ocular signs. The treatment significantly reduced lacrimation and conjunctivitis (p = 0.0001). No adverse reactions occurred. This clinical study provides evidence that NexGard® Combo is highly safe and effective for the treatment of T. callipaeda infection in cats under field conditions.

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伊沙福柳胺、伊普拉菌素和吡喹酮复方制剂(NexGard® Combo)对自然感染猫科动物中的卡氏疟原虫(Thelazia callipaeda)的疗效。
这项临床研究评估了伊沙福柳胺、伊普拉菌素和吡喹酮(NexGard® Combo)的外用复方制剂治疗自然感染眼线虫(线虫纲,Thelaziidae)的猫的疗效。在研究日(SD)0,16 只客户饲养的眼线虫感染猫被分配到未经治疗的对照组(G1,8 只)或 NexGard® Combo 治疗组(G2,8 只),并接受眼部检查。G2 组的猫按照标签建议接受治疗。在 SD 7 和 14(±1)天,检查猫是否有眼虫和临床症状。在 SD 14,收集并计数眼虫。在第 7 天和第 14 天,G1 组的所有猫仍有眼虫感染,而 G2 组的猫在第 7 天和第 14 天均无眼虫感染,表明该药物在野外条件下治疗猫的 T. callipaeda 感染具有 100% 的疗效(p ® Combo 非常安全有效)。
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来源期刊
Parasite
Parasite 医学-寄生虫学
CiteScore
5.50
自引率
6.90%
发文量
49
审稿时长
3 months
期刊介绍: Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools. All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.
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