Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy.

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2024-01-30 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae007
Qibin Han, Lang Bai, Yinhua Qian, Xiaoyu Zhang, Juan Wang, Jing Zhou, Wenguo Cui, Yuefeng Hao, Xing Yang
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Abstract

Tendinopathy is a common disorder that causes local dysfunction and reduces quality of life. Recent research has indicated that alterations in the inflammatory microenvironment play a vital role in the pathogenesis of tendinopathy. Herein, injectable methacrylate gelatin (GelMA) microspheres (GM) were fabricated and loaded with heparin-dopamine conjugate (HDC) and hepatocyte growth factor (HGF). GM@HDC@HGF were designed to balance the inflammatory microenvironment by inhibiting oxidative stress and inflammation, thereby regulating extracellular matrix (ECM) metabolism and halting tendon degeneration. Combining growth factors with heparin was expected to improve the encapsulation rate and maintain the long-term efficacy of HGF. In addition, the catechol groups on dopamine have adhesion and antioxidant properties, allowing potential attachment at the injured site, and better function synergized with HGF. GM@HDC@HGF injected in situ in rat Achilles tendinopathy (AT) models significantly down-regulated oxidative stress and inflammation, and ameliorated ECM degradation. In conclusion, the multifunctional platform developed presents a promising alternative for the treatment of tendinopathy.

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用于原位治疗肌腱病的抗氧化和消炎注射用水凝胶微球。
肌腱病是一种常见疾病,会导致局部功能障碍并降低生活质量。最近的研究表明,炎症微环境的改变在肌腱病的发病机制中起着至关重要的作用。本文制备了可注射的甲基丙烯酸酯明胶(GelMA)微球(GM),并在其中添加了肝素-多巴胺共轭物(HDC)和肝细胞生长因子(HGF)。GM@HDC@HGF旨在通过抑制氧化应激和炎症来平衡炎症微环境,从而调节细胞外基质(ECM)的新陈代谢并阻止肌腱退化。将生长因子与肝素结合有望提高包封率,并保持 HGF 的长期功效。此外,多巴胺上的儿茶酚基团具有粘附性和抗氧化性,可附着在受伤部位,并与 HGF 发挥更好的协同作用。将 GM@HDC@HGF 原位注射到大鼠跟腱病(AT)模型中,可显著降低氧化应激和炎症反应,改善 ECM 降解。总之,所开发的多功能平台为治疗肌腱病提供了一种前景广阔的选择。
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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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