Hyperdense sign as a predictor for successful recanalization and clinical outcome in acute ischemic stroke: A systematic review and meta-analysis.

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY Interventional Neuroradiology Pub Date : 2024-02-28 DOI:10.1177/15910199241235431

Khaled Gharaibeh, Nameer Aladamat, Mohammad Samara, Adam T Mierzwa, Ahsan Ali, Syed Zaidi, Mouhammad Jumaa

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Abstract

Objective: To assess the prognostic values of hyperdense sign on pretreatment non-contrast head CT scan for successful recanalization (mTICI ≥2b) and 90-day good functional outcome (mRs 0-2) in patients with acute ischemic stroke undergoing mechanical thrombectomy (MT).

Methods: Literature search on PubMed, EMBASE, and Cochrane databases from inception up to 1 November 2023 was conducted. Twelve studies which reported hyperdense sign, recanalization and clinical outcomes were included in qualitative synthesis and meta-analysis.

Results: Pooled analysis demonstrated a statistically significant association between successful recanalization and hyperdense sign-positive patients who underwent MT (odd ratios (OR) = 1.47, 95% confidence interval (CI) = 1.03-2.10, p = 0.04). No statistically significant association was demonstrated between presence of hyperdense sign and good functional outcome (OR = 1.04, 95% CI: 0.72-1.49, p = 0.85) or symptomatic intracranial hemorrhage sICH (OR: 1.80, 95% CI 0.72-4.47, p = 0.21).

Conclusions: This meta-analysis demonstrated that pre-intervention hyperdense sign on CT imaging might be useful in prediction of successful recanalization after MT.

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高密度征是急性缺血性脑卒中再通成功率和临床预后的预测指标：系统回顾和荟萃分析。

目的评估接受机械取栓术（MT）的急性缺血性脑卒中患者治疗前非对比度头部 CT 扫描高密度征对成功再通（mTICI ≥2b）和 90 天良好功能预后（mRs 0-2）的预后价值：方法：在 PubMed、EMBASE 和 Cochrane 数据库中进行文献检索，检索时间从开始至 2023 年 11 月 1 日。定性综合和荟萃分析纳入了报告高密度征象、再通和临床结果的 12 项研究：汇总分析表明，成功再通畅与接受MT的高密度征阳性患者之间存在统计学意义上的显著关联（奇数比（OR）=1.47，95%置信区间（CI）=1.03-2.10，P=0.04）。高密度征与良好功能预后（OR = 1.04，95% CI：0.72-1.49，p = 0.85）或无症状性颅内出血 sICH（OR：1.80，95% CI 0.72-4.47，p = 0.21）之间无统计学意义：这项荟萃分析表明，干预前的 CT 成像高密度征可能有助于预测 MT 后的成功再通。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Interventional Neuroradiology CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

3.60

自引率

11.80%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Interventional Neuroradiology (INR) is a peer-reviewed clinical practice journal documenting the current state of interventional neuroradiology worldwide. INR publishes original clinical observations, descriptions of new techniques or procedures, case reports, and articles on the ethical and social aspects of related health care. Original research published in INR is related to the practice of interventional neuroradiology...