Hexasomal particles: consequence or also consequential?

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-02-26 DOI:10.1016/j.gde.2024.102163
Upneet Kaur , Elise N Muñoz , Geeta J Narlikar
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Abstract

It is long known that an RNA polymerase transcribing through a nucleosome can generate subnucleosomal particles called hexasomes. These particles lack an H2A–H2B dimer, breaking the symmetry of a nucleosome and revealing new interfaces. Whether hexasomes are simply a consequence of RNA polymerase action or they also have a regulatory impact remains an open question. Recent biochemical and structural studies of RNA polymerases and chromatin remodelers with hexasomes motivated us to revisit this question. Here, we build on previous models to discuss how formation of hexasomes can allow sophisticated regulation of transcription and also significantly impact chromatin folding. We anticipate that further cellular and biochemical analysis of these subnucleosomal particles will uncover additional regulatory roles.\

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六面体微粒:结果还是后果?
人们早就知道,RNA 聚合酶通过核小体转录时会产生称为六聚体的亚核小体颗粒。这些颗粒缺少 H2A-H2B 二聚体,打破了核小体的对称性,并显示出新的界面。六聚体究竟只是 RNA 聚合酶作用的结果,还是也有调控作用,这仍是一个未决问题。最近对 RNA 聚合酶和染色质重塑酶与六聚体的生化和结构研究促使我们重新审视这个问题。在此,我们以先前的模型为基础,讨论了六聚体的形成如何能够对转录进行复杂的调控,并对染色质折叠产生重大影响。我们预计,对这些亚核糖体颗粒的进一步细胞和生化分析将发现更多的调控作用。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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