Effect of Hindlimb Unloading on Hamstring Muscle Activity in Rats.

IF 2.1 4区心理学 Q3 BEHAVIORAL SCIENCES Brain Behavior and Evolution Pub Date : 2024-01-01 Epub Date: 2024-02-27 DOI:10.1159/000537776

Alexander Popov, Vsevolod Lyakhovetskii, Oleg Gorskii, Daria Kalinina, Natalia Pavlova, Pavel Musienko

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Abstract

Introduction: The changes in knee axial rotation play an important role in traumatic and non-traumatic knee disorders. It is known that support afferentation can affect the axial rotator muscles. The condition of innervation of the semitendinosus (ST) and biceps femoris posterior (BFp) has changed in non-terrestrial and terrestrial vertebrates in evolution; thus, we hypothesized this situation might be replayed by hindlimb unloading (HU).

Methods: In the present study, the EMG activity of two hamstring muscles, m. ST and m. BFp, which are antagonists in axial rotation of the tibia, was examined before and after 7 days of HU.

Results: During locomotion and swimming, the ST flexor burst activity increased in the stance-to-swing transition and in the retraction-protraction transition, respectively, while that of BFp remained unchanged. Both ST and BFp non-burst extensor activity increased during stepping and decreased during swimming.

Conclusions: Our results show that (1) the flexor burst activity of ST and BFp depends differently on the load-dependent sensory input in the step cycle; (2) shift of the activity gradient towards ST in the stance-to-swing transition could produce excessive internal tibia torque, which can be used as an experimental model of non-traumatic musculoskeletal disorders; and (3) the mechanisms of activity of ST and BFp may be based on reciprocal activity of homologous muscles in primary tetrapodomorph and depend on the increased role of supraspinal control.

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后肢卸载对大鼠腿筋肌肉活动的影响

简介膝关节轴向旋转的变化在创伤性和非创伤性膝关节疾病中起着重要作用。众所周知，支撑传入可影响轴旋转肌。ST和BFp的神经支配条件在非陆生和陆生脊椎动物的进化过程中发生了变化，因此我们假设这种情况可能会在后肢卸载（HU）时重现：本研究对胫骨轴向旋转中的拮抗剂--半腱肌（ST）和股二头肌后侧（BFp）这两块腘绳肌的肌电图活动进行了检测：结果：在运动和游泳过程中，ST屈肌爆发活动分别在站立到摆动的过渡阶段和回缩到回缩的过渡阶段有所增加，而BFp的活动则保持不变。ST和BFp的非爆发性伸肌活动在迈步时增加，在游泳时减少：我们的研究结果表明结论：我们的研究结果表明：1）ST 和 BFp 的屈肌爆发活动对步进周期中与负荷相关的感觉输入的依赖程度不同。2）在从站立到摆动的转换过程中，活动梯度向 ST 的转移会产生过大的胫骨内扭矩，这可作为非创伤性肌肉骨骼疾病的实验模型。3）ST 和 BFp 的活动机制可能基于原生四足动物同源肌肉的相互活动，并取决于脊髓上控制作用的增强。

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来源期刊

Brain Behavior and Evolution 医学-行为科学

CiteScore

3.10

自引率

23.50%

发文量

审稿时长

>12 weeks

期刊介绍： ''Brain, Behavior and Evolution'' is a journal with a loyal following, high standards, and a unique profile as the main outlet for the continuing scientific discourse on nervous system evolution. The journal publishes comparative neurobiological studies that focus on nervous system structure, function, or development in vertebrates as well as invertebrates. Approaches range from the molecular over the anatomical and physiological to the behavioral. Despite this diversity, most papers published in ''Brain, Behavior and Evolution'' include an evolutionary angle, at least in the discussion, and focus on neural mechanisms or phenomena. Some purely behavioral research may be within the journal’s scope, but the suitability of such manuscripts will be assessed on a case-by-case basis. The journal also publishes review articles that provide critical overviews of current topics in evolutionary neurobiology.