Association of Interleukin-17A and Interleukin-17F Gene Polymorphisms with Atopic Dermatitis in Chinese Children.

IF 1.1 4区 生物学 Q4 GENETICS & HEREDITY Genetic testing and molecular biomarkers Pub Date : 2024-02-01 DOI:10.1089/gtmb.2023.0379
Chen Shen, Yunling Li, Jian Huang, Jing Li, Guoqiang Qi, Zhu Zhu, Huiwen Zheng
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Abstract

Background: Atopic dermatitis (AD) is a chronic, recurrent inflammatory disease associated with an unbalanced immune response in the upper layers of the skin tissue, mostly starting in childhood. As important factors in gene expression regulation, polymorphisms in interleukin (IL)-17A and IL-17F may be associated with the susceptibility and severity of AD. Methods: Blood samples and clinical information were obtained from 132 patients with AD and 100 healthy children. Using multiplex polymerase chain reaction and next-generation sequencing, five potential single-nucleotide polymorphisms (SNPs) of IL-17A and IL-17F were genotyped in all participants. The relationship between SNPs and susceptibility to or severity of AD was examined by analyzing haplotypes and genetic models. Results: The IL-17A rs3819025 polymorphism was substantially associated with higher AD risk in both the allele model (p = 0.03; odds ratio [OR] = 1.76; confidence interval [CI]: 1.05-2.95) and the dominant model (p = 0.04, OR = 1.85; CI: 1.03-3.33). There was no correlation between AD susceptibility and the IL-17A (rs2275913 and rs4711998) or IL-17F (rs763780 and rs12203736) SNPs (all p > 0.05). Additionally, the five IL-17A and IL-17F SNPs did not significantly differ across the mild-to-moderate and severe subgroups (all p > 0.05). Conclusions: The IL-17A/rs3819025 polymorphism was linked to the development of AD, whereas the IL-17F polymorphism was unrelated to the susceptibility to and severity of AD. The IL-17A polymorphism may provide valuable information to speculate on the susceptibility to AD in Chinese Han children.

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白细胞介素-17A和白细胞介素-17F基因多态性与中国儿童特应性皮炎的关系
背景:特应性皮炎(AD)是一种慢性、反复发作的炎症性疾病,与皮肤上层组织不平衡的免疫反应有关,大多始于儿童时期。作为基因表达调控的重要因素,白细胞介素(IL)-17A 和 IL-17F 的多态性可能与特应性皮炎的易感性和严重程度有关。研究方法采集 132 名 AD 患者和 100 名健康儿童的血样和临床信息。利用多重聚合酶链反应和新一代测序技术,对所有参与者的 IL-17A 和 IL-17F 的五个潜在单核苷酸多态性(SNPs)进行了基因分型。通过分析单倍型和遗传模型,研究了SNPs与AD易感性或严重程度之间的关系。结果显示在等位基因模型(P = 0.03;比值比 [OR] = 1.76;置信区间 [CI]:1.05-2.95)和显性模型(P = 0.04,OR = 1.85;CI:1.03-3.33)中,IL-17A rs3819025多态性与较高的AD风险有很大关系。AD易感性与IL-17A(rs2275913和rs4711998)或IL-17F(rs763780和rs12203736)SNP之间没有相关性(所有P>0.05)。此外,五个 IL-17A 和 IL-17F SNPs 在轻中度亚组和重度亚组中没有显著差异(均 p > 0.05)。结论IL-17A/rs3819025多态性与AD的发病有关,而IL-17F多态性与AD的易感性和严重程度无关。IL-17A多态性可为推测中国汉族儿童对AD的易感性提供有价值的信息。
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来源期刊
CiteScore
2.50
自引率
7.10%
发文量
63
审稿时长
1 months
期刊介绍: Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results. Genetic Testing and Molecular Biomarkers coverage includes: -Diagnosis across the life span- Risk assessment- Carrier detection in individuals, couples, and populations- Novel methods and new instrumentation for genetic testing- Results of molecular, biochemical, and cytogenetic testing- Genetic counseling
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