Neuroprotective effects of rosemary extract on white matter of prefrontal cortex in old rats.

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Iranian Journal of Basic Medical Sciences Pub Date : 2024-01-01 DOI:10.22038/IJBMS.2023.74168.16117
Mohsen Eslami Farsani, Shahnaz Razavi, Homa Rasoolijazi, Ebrahim Esfandiari, Reihaneh Seyedebrahimi, Shima Ababzadeh
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Abstract

Objectives: During aging, cerebral structures undergo changes due to oxidative stress. The consumption of some plants seems to improve neurological health. For example, rosemary extract (RE) which is widely used as a flavoring food has anti-inflammatory and anti-oxidant activities. Therefore, we aimed to study the effect of RE on the changes related to the aging process in the prefrontal cortex (PFC).

Materials and methods: Twenty-four male Wistar rats including young and old were purchased. Each group was divided into two subgroups: vehicle and rosemary (old vehicle (OV), old rosemary (OR), young vehicle (YV), and young rosemary (YR) groups). Then, we examined the number of intact neurons, myelin base protein (MBP), white matter (WM), levels of malondialdehyde (MDA), and glutathione peroxidase (GPx) in the PFC.

Results: The results showed that in the old vehicle rats compared to the young group without treatment, except for the MDA level (which increased), other variables significantly decreased (P≤0.05). Additionally, RE consumption demonstrated a significant elevation of WMA, MBP intensity, number of intact neurons, and GPx activity level, while MDA levels significantly reduced in the treated old rats compared to the old vehicle group (P≤0.05). However, there was no significant difference between the OR and YV groups (P≥0.05).

Conclusion: Overall, it seems that RE can protect and improve aging damages in the PFC due to its anti-oxidant properties. So, the use of RE can be a suitable strategy to prevent aging complications in the brain.

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迷迭香提取物对老年大鼠前额叶皮质白质的神经保护作用
目的:在衰老过程中,大脑结构会因氧化压力而发生变化。食用某些植物似乎可以改善神经系统健康。例如,被广泛用作调味食品的迷迭香提取物(RE)具有抗炎和抗氧化活性。因此,我们旨在研究迷迭香提取物对前额叶皮质(PFC)衰老过程相关变化的影响:购买 24 只雄性 Wistar 大鼠,包括年轻人和老年人。每组分为两个亚组:载体组和迷迭香组(老载体组(OV)、老迷迭香组(OR)、年轻载体组(YV)和年轻迷迭香组(YR))。然后,我们检测了 PFC 中完整神经元的数量、髓鞘基质蛋白(MBP)、白质(WM)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GPx)的水平:结果表明,与未接受治疗的年轻组相比,老年载体大鼠除 MDA 水平升高外,其他变量均显著下降(P≤0.05)。此外,与老龄载体组相比,服用 RE 的老龄大鼠的 WMA、MBP 强度、完整神经元数量和 GPx 活性水平均有显著提高,而 MDA 水平则显著降低(P≤0.05)。然而,OR 组和 YV 组之间没有明显差异(P≥0.05):总之,RE 的抗氧化特性似乎可以保护和改善全氟化碳的老化损伤。因此,使用 RE 可以作为预防大脑衰老并发症的一种合适策略。
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来源期刊
Iranian Journal of Basic Medical Sciences
Iranian Journal of Basic Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-PHARMACOLOGY & PHARMACY
CiteScore
4.00
自引率
4.50%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . The Journal of "IJBMS” is a modern forum for scientific communication. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, Microbiology, Pathology, Pharmacology, Pharmaceutical Sciences, and Physiology, will be published after they have been peer reviewed. This will also include reviews and multidisciplinary research.
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