V. N. Chandra Sekhar , Gorle Simhachalam , L. Vaikunta Rao , A. V. Dhanunjaya Rao , Madhavaram Shankar , Akula Raghunadh
{"title":"An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO2 as a robust recyclable catalyst","authors":"V. N. Chandra Sekhar , Gorle Simhachalam , L. Vaikunta Rao , A. V. Dhanunjaya Rao , Madhavaram Shankar , Akula Raghunadh","doi":"10.1080/00397911.2024.2320398","DOIUrl":null,"url":null,"abstract":"<div><p>A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO<sub>2</sub> as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder conditions in a short reaction time of 2-3 hours. The use of a less expensive catalyst makes this protocol more convenient. SiO<sub>2</sub> has been identified as a convenient catalyst for the synthesis and can be reused for up to three cycles.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791124000146","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO2 as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder conditions in a short reaction time of 2-3 hours. The use of a less expensive catalyst makes this protocol more convenient. SiO2 has been identified as a convenient catalyst for the synthesis and can be reused for up to three cycles.
期刊介绍:
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.