V. N. Chandra Sekhar , Gorle Simhachalam , L. Vaikunta Rao , A. V. Dhanunjaya Rao , Madhavaram Shankar , Akula Raghunadh
{"title":"An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO2 as a robust recyclable catalyst","authors":"V. N. Chandra Sekhar , Gorle Simhachalam , L. Vaikunta Rao , A. V. Dhanunjaya Rao , Madhavaram Shankar , Akula Raghunadh","doi":"10.1080/00397911.2024.2320398","DOIUrl":null,"url":null,"abstract":"<div><p>A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO<sub>2</sub> as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder conditions in a short reaction time of 2-3 hours. The use of a less expensive catalyst makes this protocol more convenient. SiO<sub>2</sub> has been identified as a convenient catalyst for the synthesis and can be reused for up to three cycles.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 7","pages":"Pages 526-535"},"PeriodicalIF":1.8000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791124000146","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/28 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO2 as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder conditions in a short reaction time of 2-3 hours. The use of a less expensive catalyst makes this protocol more convenient. SiO2 has been identified as a convenient catalyst for the synthesis and can be reused for up to three cycles.
期刊介绍：
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.
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