Comparison of lipidome profiles in human milk from Chinese Han and Korean ethnic groups based on high-throughput lipidomic techniques

IF 3.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Dairy Science Pub Date : 2024-07-01 DOI:10.3168/jds.2023-23610

Yuxue Sun , Jiafei Liu , Xiaowen Pi , Shilong Jiang , Jianjun Cheng , Mingruo Guo

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Abstract

The composition of milk lipids varies across different ethnic sources. The lipidome profiles of Chinese Han human milk (HHM) and Chinese Korean human milk (KHM) were investigated in this study. A total of 741 lipids were identified in HHM and KHM. Twenty-eight differentially expressed lipids (DEL) were screened between the 2 milk groups; among these, 6 triacylglycerols (TG), 13 diacylglycerols (DG), 7 free fatty acids (FFA), and 1 monoglyceride (MG) were upregulated in KHM. Carnitine (CAR) was upregulated in HHM. Most DEL showed a single peak distribution in both groups. The correlations, related pathways and diseases of these DEL were further analyzed. The results demonstrated that DG, MG, and FFA showed highly positive correlations with each other (r > 0.8). The most enriched Kyoto Encyclopedia of Genes and Genomes (https://www.kegg.jp/kegg/) and Human Metabolome Database (http://www.hmdb.ca) pathways were inositol phosphate metabolism, and α-linolenic acid and linolenic acid metabolism, respectively. Major depressive disorder-related FFA (20:5) and FFA (22:6) were more abundant in KHM, whereas HHM showed more obesity-related CAR. These data potentially provide lipidome information regarding human milk from different ethnicities in China.

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基于 UPLC-QTRAP-MS/MS 的中国汉族和朝鲜族母乳脂质体图谱比较

不同人种的母乳脂质组成各不相同。本研究调查了中国汉族人乳（HHM）和中国朝鲜族人乳（KHM）的脂质组图谱。共鉴定了中国汉族人乳和朝鲜族人乳中的 741 种脂质。筛选出两组母乳中 28 种差异表达的脂质（DELs）；其中，6 种三酰甘油（TGs）、13 种二酰甘油（DGs）、7 种游离脂肪酸（FFAs）和 1 种单甘油酯（MGs）在 KHM 中上调。肉碱（CAR）在 HHM 中上调。大多数 DELs 在两组中均呈单峰分布。研究人员进一步分析了这些 DELs 的相关性、相关途径和疾病。结果表明，DG、MG 和 FFAs 之间呈高度正相关（r >0.8）。京都基因与基因组百科全书（KEGG）和人类代谢组数据库（HMDB）中最富集的通路分别是磷酸肌醇代谢、α-亚麻酸和亚麻酸代谢。重度抑郁障碍相关的FFA（20:5）和FFA（22:6）在KHM中更为丰富，而HHM则显示出更多与肥胖相关的CAR。这些数据有可能为中国不同民族的母乳提供脂质体信息。

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来源期刊

Journal of Dairy Science 农林科学-奶制品与动物科学

CiteScore

7.90

自引率

17.10%

发文量

784

审稿时长

4.2 months

期刊介绍： The official journal of the American Dairy Science Association®, Journal of Dairy Science® (JDS) is the leading peer-reviewed general dairy research journal in the world. JDS readers represent education, industry, and government agencies in more than 70 countries with interests in biochemistry, breeding, economics, engineering, environment, food science, genetics, microbiology, nutrition, pathology, physiology, processing, public health, quality assurance, and sanitation.