Dose-response relationship between lung function and chest imaging response to silica exposures in artificial stone manufacturing workers.

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2024-03-02 DOI:10.1186/s12940-024-01067-1
Chi-Hsien Chen, Perng-Jy Tsai, Wen-Wen Chang, Cheng-Yao Chen, Chih-Yong Chen, Deborah Yates, Yue Leon Guo
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Abstract

Background: Occupational exposure to artificial stone, a popular material used for countertops, can cause accelerated silicosis, but the precise relationship between silica dose and disease development is unclear.

Objectives: This study evaluated the impact of silica exposure on lung function and chest imaging in artificial stone manufacturing workers.

Methods: Questionnaire and spirometry assessments were administered to workers in two plants. A high-exposure subset underwent further evaluation, including chest CT and DLco. Weighting factors, assigned as proxies for silica exposure, were based on work tasks. Individual cumulative exposures were estimated using area concentration measurements and time spent in specific areas. Exposure-response associations were analyzed using linear and logistic regression models.

Results: Among 65 participants, the mean cumulative silica exposure was 3.61 mg/m3-year (range 0.0001 to 44.4). Each 1 mg/m3-year increase was associated with a 0.46% reduction in FVC, a 0.45% reduction in FEV1, and increased lung function abnormality risk (aOR = 1.27, 95% CI = 1.03-1.56). Weighting factors correlated with cumulative exposures (Spearman correlation = 0.59, p < 0.0001), and weighted tenure was associated with lung function abnormalities (aOR = 1.04, 95% CI = 1.01-1.09). Of 37 high-exposure workers, 19 underwent chest CT, with 12 (63%) showing abnormal opacities. Combining respiratory symptoms, lung function, and chest X-ray achieved 91.7% sensitivity and 75% specificity for predicting chest CT abnormalities.

Conclusion: Lung function and chest CT abnormalities occur commonly in artificial stone workers. For high-exposure individuals, abnormalities on health screening could prompt further chest CT examination to facilitate early silicosis detection.

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人造石生产工人肺功能和胸部成像对二氧化硅暴露的剂量反应关系。
背景:人造石是一种常用的台面材料,职业暴露于人造石可能会导致加速性矽肺,但二氧化硅剂量与疾病发展之间的确切关系尚不清楚:本研究评估了矽暴露对人造石生产工人肺功能和胸部成像的影响:方法:对两家工厂的工人进行问卷调查和肺活量评估。方法:对两家工厂的工人进行问卷调查和肺活量评估,并对高暴露人群进行进一步评估,包括胸部 CT 和 DLco。根据工作任务分配加权因子,作为二氧化硅暴露的替代物。利用区域浓度测量值和在特定区域停留的时间来估算个人的累积暴露量。采用线性和逻辑回归模型分析暴露与反应之间的关联:在 65 名参与者中,平均累积二氧化硅暴露量为 3.61 毫克/立方米-年(范围为 0.0001 至 44.4)。每增加 1 毫克/立方米-年,FVC 降低 0.46%,FEV1 降低 0.45%,肺功能异常风险增加(aOR = 1.27,95% CI = 1.03-1.56)。加权因子与累积暴露相关(Spearman 相关性 = 0.59,p 结论:肺功能和胸部 CT 异常与累积暴露相关:人造石工人的肺功能和胸部 CT 异常很常见。对于高暴露人群,健康筛查中的异常情况可促使进一步进行胸部 CT 检查,以便及早发现矽肺病。
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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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