Keila Rufatto de Souza, Nicole Alessandra Engel, Hevylin Jacinto Soares, Catarina Barbosa Chaves Bressan, Larissa Marques Dela Vedova, Larissa Espindola da Silva, Talita Farias Mendes, Mariella Reinol da Silva, Mariana Pacheco de Oliveira, Amanda Indalecio Goulart, Emily Córneo, Heloísa de Medeiros Borges, Monique Michels, João Vitor Silvano Bittencourt, Laura de Roch Casagrande, Gabriela Kozuchovski Ferreira, Fabricia Cardoso Petronilho, Felipe Dal-Pizzol, Paulo Cesar Lock Silveira, Rafael Mariano de Bitencourt, Marina Goulart da Silva, Gislaine Tezza Rezin
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引用次数: 0
Abstract
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is classified as a low-grade chronic inflammatory disease and has associated comorbidities. Different nutritional strategies are used for the purpose of weight loss, highlighting low-carbohydrate (LC) diets, ketogenic diets, and intermittent fasting (IF). These strategies can lead to metabolic and behavioral changes as they stimulate different biochemical pathways. Therefore, this study evaluated memory, energy metabolism, neuroinflammation, oxidative stress, and antioxidant defense parameters in mice subjected to an LC diet, ketogenic diet (KD), or IF. Eighty male Swiss mice, 60 days old, were divided into 4 groups: control, LC, KD, or IF. Body weight was measured weekly, and food intake every 48 h. After 15 days of nutritional interventions, the animals were subjected to the behavioral object recognition test and subsequently euthanized. Then, visceral fat was removed and weighed, and the brain was isolated for inflammatory and biochemical analysis. We concluded from this study that the LC and KD strategies could damage memory, IF improves the production of adenosine triphosphate (ATP), and the LC, KD, and IF strategies do not lead to neuroinflammatory damage but present damage at the level of oxidative stress.
期刊介绍:
Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.