Non-coding DNA variants for risk in lupus

IF 4.5 2区医学 Q1 RHEUMATOLOGY Best Practice & Research in Clinical Rheumatology Pub Date : 2024-05-01 DOI:10.1016/j.berh.2024.101937

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Abstract

Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that arises from a dynamic interplay between genetics and environmental triggers. The advent of sophisticated genomics technology has catalyzed a shift in our understanding of disease etiology, spotlighting the pivotal role of non-coding DNA variants in SLE pathogenesis. In this review, we present a comprehensive examination of the non-coding variants associated with SLE, shedding light on their role in influencing disease risk and progression. We discuss the latest methodological advancements that have been instrumental in the identification and functional characterization of these genomic elements, with a special focus on the transformative power of CRISPR-based gene-editing technologies. Additionally, the review probes into the therapeutic opportunities that arise from modulating non-coding regions associated with SLE. Through an exploration of the complex network of non-coding DNA, this review aspires to decode the genetic puzzle of SLE and set the stage for groundbreaking gene-based therapeutic interventions and the advancement of precision medicine strategies tailored to SLE management.

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红斑狼疮风险的非编码 DNA 变异。

系统性红斑狼疮（SLE）是一种多因素自身免疫性疾病，由遗传和环境诱因之间的动态相互作用引起。尖端基因组学技术的出现促使我们对疾病病因学的认识发生了转变，凸显了非编码 DNA 变异在系统性红斑狼疮发病机制中的关键作用。在这篇综述中，我们对与系统性红斑狼疮相关的非编码变异进行了全面研究，揭示了它们在影响疾病风险和进展方面的作用。我们讨论了在鉴定这些基因组元素并对其进行功能表征方面取得的最新方法学进展，并特别关注了基于 CRISPR 的基因编辑技术的变革性力量。此外，这篇综述还探讨了调节与系统性红斑狼疮相关的非编码区所带来的治疗机会。通过探索复杂的非编码DNA网络，这篇综述希望破解系统性红斑狼疮的基因谜题，为基于基因的开创性治疗干预和针对系统性红斑狼疮管理的精准医疗策略的发展奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.