Laboratory evaluation of lipid parameters in clinical practice

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Indian heart journal Pub Date : 2024-03-01 DOI:10.1016/j.ihj.2024.02.002
A.K. Pancholia , Nitin Kumar Kabra , Rajeev Gupta
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Abstract

Accurate measurement of various lipids- total cholesterol, cholesterol lipoproteins and triglycerides- is important for coronary artery disease (CAD) prevention and management. Over the years many technologies have developed for their accurate measurements and in recent years the assays have been internationally standardised. Most of the guidelines recommend measurement of non fasting levels of total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C) and triglycerides (TG) for risk estimation and guiding treatment. Measurement of lipid profile in clinics and emergency departments can lead to earlier estimation of CAD risk and rapid initiation of lipid lowering therapy. CAD risk and baseline levels of LDL-C guide intensity of lipid lowering therapies. The LDL-C targets according to CAD risk are detailed in this review. There is an urgent need for standardization of lipid estimation in medical laboratories across the country so that every eligible individual can receive evidence-based lipid lowering interventions.

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临床实践中血脂参数的实验室评估。
准确测量各种血脂--总胆固醇、胆固醇脂蛋白和甘油三酯--对于冠状动脉疾病(CAD)的预防和管理非常重要。多年来,许多精确测量血脂的技术不断发展,近年来,这些检测方法已实现国际标准化。大多数指南都建议测量非空腹水平的总胆固醇、低密度脂蛋白胆固醇 (LDL-C)、高密度脂蛋白胆固醇 (HDL-C)、非高密度脂蛋白胆固醇 (non-HDL-C) 和甘油三酯 (TG),以评估风险和指导治疗。在诊所和急诊科测量血脂谱可以更早地估计 CAD 风险并迅速开始降脂治疗。CAD 风险和 LDL-C 基线水平可指导降脂治疗的强度。本综述详细介绍了根据 CAD 风险确定的 LDL-C 目标值。目前迫切需要在全国范围内实现医学实验室血脂估测的标准化,以便每个符合条件的人都能接受循证降脂干预。
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来源期刊
Indian heart journal
Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.60
自引率
6.70%
发文量
82
审稿时长
52 days
期刊介绍: Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.
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