Correlation between COVID-19 infection and fetal situs inversus

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY Birth Defects Research Pub Date : 2024-03-05 DOI:10.1002/bdr2.2324

Shuo Qiu, Shuang Wu, Ranran Yin, Bo Wang, Hongying Wu

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Abstract

Background

Situs inversus is a rare congenital condition, defined by the mirror-image transposition of the abdominothoracic organs. It is linked to an increased risk of different disorders, for example, congenital heart defects and primary ciliary dyskinesia. Recently, some reports have been on the increased incidence of situs inversus after the COVID-19 pandemic.

Objectives

To investigate the association between maternal COVID-19 infection and fetal situs inversus occurrence risk.

Methods

All pregnant women who underwent fetal ultrasound examinations at Jinan Maternal and Child Health Hospital from January to May of 2022 and 2023 were recruited. A chi-square test was conducted to assess the association of maternal COVID-19 infection with the incidence rate of fetal situs inversus.

Results

A total of 8381 patients, including 25 with situs inversus fetuses were recruited. A total of 3956 patients had COVID-19, while 4400 did not. Among 25 mothers with situs inversus fetuses, 22 had COVID-19 and 3 without recent infection. Our analysis showed a strong link between COVID-19 and a higher risk of fetus situs inversus (P < .001, odds ratio 8.196).

Conclusion

Maternal COVID-19 infection in the early stages of the pregnancy is associated with an increased risk of fetal situs inversion occurrence. Therefore, further research in this field seems necessary.

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COVID-19感染与胎位不正之间的相关性。

背景：腹腔内翻位是一种罕见的先天性疾病，是指腹腔和胸腔器官的镜像转位。它与罹患各种疾病的风险增加有关，例如先天性心脏缺陷和原发性睫状肌运动障碍。最近，有报道称 COVID-19 大流行后，坐位倒置的发病率有所增加：研究母体感染 COVID-19 与胎儿发生坐位不正风险之间的关系：方法：招募2022年和2023年1月至5月在济南市妇幼保健院接受胎儿超声检查的所有孕妇。采用卡方检验评估母体COVID-19感染与胎儿坐位不正发生率的相关性：结果：共招募了 8381 名患者，其中包括 25 名坐位倒置胎儿患者。共有 3956 名患者感染了 COVID-19，4400 名患者未感染。在 25 位患有坐位难产的母亲中，22 位患有 COVID-19，3 位近期未感染。我们的分析表明，COVID-19 与胎儿发生坐位不正的较高风险之间存在密切联系（P 结论：COVID-19 与胎儿发生坐位不正的较高风险之间存在密切联系：孕早期母体感染 COVID-19 与胎儿发生坐位倒置的风险增加有关。因此，有必要在这一领域开展进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.