Heat therapy in rheumatic and musculoskeletal diseases - an overview of clinical and molecular effects.

IF 3 3区 医学 Q2 ONCOLOGY International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-03-04 DOI:10.1080/02656736.2024.2322667
Philipp Klemm, Nils Schulz, Priyanka Boettger, Uwe Lange
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Abstract

Rheumatic and musculoskeletal diseases (RMDs) usually lead to morphological and functional deficits of various extend, increased morbidity and a considerable loss of quality of life. Modern pharmacological treatment has become effective and can stop disease progression. Nonetheless, disease progression is often only slowed down. Moreover, pharmacological treatment does not improve functionality per se. Therefore, multimodal treatment of rheumatic disorders with physical therapy being a key element is of central importance for best outcomes. In recent years, research into physical medicine shifted from a sole investigation of its clinical effects to a combined investigation of clinical effects and potential changes in the molecular level (e.g., inflammatory cytokines and the cellular autoimmune system), thus offering new explanations of clinical effects of physical therapy. In this review we provide an overview of studies investigating different heat applications in RMDs, their effect on disease activity, pain and their influence on the molecular level.

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风湿病和肌肉骨骼疾病的热疗--临床和分子效应概述。
风湿病和肌肉骨骼疾病(RMDs)通常会导致不同程度的形态和功能障碍、发病率增加以及生活质量大幅下降。现代药物治疗非常有效,可以阻止疾病的发展。然而,疾病的进展往往只能延缓。此外,药物治疗本身并不能改善功能。因此,以物理治疗为关键因素的风湿性疾病多模式治疗对于取得最佳疗效至关重要。近年来,物理医学研究从单纯研究其临床效果转向综合研究临床效果和分子水平的潜在变化(如炎症细胞因子和细胞自身免疫系统),从而为物理治疗的临床效果提供了新的解释。在这篇综述中,我们概述了对 RMD 中不同热应用的研究,以及这些热应用对疾病活动、疼痛的影响及其对分子水平的影响。
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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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