Sigmoidal relationship between liver fat content and nonalcoholic fatty liver disease in Chinese adults.

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL Postgraduate Medical Journal Pub Date : 2024-07-18 DOI:10.1093/postmj/qgae025

Pingping Yu, Huachao Yang, Hu Li, Ying Mei, Yuanyuan Wu, Hongfeng Cheng, Huiru Su, Yueling Deng, Tao Jiang, Zhongxiang He, Peng Hu

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Abstract

Purpose: To explore the relationship between liver fat content (LFC) and nonalcoholic fatty liver disease (NAFLD) and determine the new threshold of LFC to diagnose NAFLD.

Methods: The data from questionnaire survey, general physical examination, laboratory examination, and image examination were collected. Multivariate regression analysis, receiver operating characteristic curve analysis, smooth curve fitting, and threshold effect analysis were performed using the R software to investigate the relationship between LFC and NAFLD and to identify the new threshold of LFC to diagnose NAFLD.

Results: The prevalence of NAFLD was 30.42%, with a significantly higher prevalence in men than in women. Regression analyses demonstrated that LFC odds ratio [95% confidence interval (CI)] was 1.28 (95% CI: 1.24-1.31) in fully-adjust model. Analysis of the LFC quartile, with Q1 as a reference, revealed that the odds ratios of NAFLD were 1.47 (95% CI: 1.08-1.99), 2.29 (95% CI: 1.72-3.06), and 10.02 (95% CI: 7.45-13.47) for Q2, Q3, and Q4 groups, respectively. Smooth curve fitting and threshold effect analysis displayed a nonlinear relationship between LFC and NAFLD, and the threshold was 4.5%. The receiver operating characteristic curve indicated that when LFC was 4.5%, the area under curve (95% CI) was 0.80 (0.79-0.82), and the sensitivity and specificity of LFC in diagnosing NAFLD were 0.64% and 0.82%, respectively.

Conclusion: The relationship between LFC and NAFLD was sigmoidal, with an inflection point of 4.5%.

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中国成年人肝脏脂肪含量与非酒精性脂肪肝之间的曲线关系

目的：探讨肝脏脂肪含量（LFC）与非酒精性脂肪肝（NAFLD）之间的关系，并确定诊断非酒精性脂肪肝的新阈值：方法：收集问卷调查、一般体格检查、实验室检查和影像学检查的数据。利用 R 软件进行多元回归分析、接收器操作特征曲线分析、平滑曲线拟合和阈值效应分析，研究 LFC 与非酒精性脂肪肝的关系，并确定诊断非酒精性脂肪肝的新阈值：非酒精性脂肪肝的患病率为30.42%，男性患病率明显高于女性。回归分析表明，在完全调整模型中，LFC几率比[95%置信区间（CI）]为1.28（95% CI：1.24-1.31）。以 Q1 为参照，对 LFC 四分位数进行分析后发现，Q2、Q3 和 Q4 组的非酒精性脂肪肝几率比分别为 1.47（95% CI：1.08-1.99）、2.29（95% CI：1.72-3.06）和 10.02（95% CI：7.45-13.47）。平滑曲线拟合和阈值效应分析表明，LFC 与非酒精性脂肪肝之间存在非线性关系，阈值为 4.5%。接收者操作特征曲线显示，当LFC为4.5%时，曲线下面积（95% CI）为0.80（0.79-0.82），LFC诊断非酒精性脂肪肝的敏感性和特异性分别为0.64%和0.82%：结论：LFC与非酒精性脂肪肝之间呈曲线关系，拐点为4.5%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medical Journal 医学-医学：内科

CiteScore

8.50

自引率

2.00%

发文量

131

审稿时长

2.5 months

期刊介绍： Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.