Hameed Muddassar, Mengli Chen, Tong Zhang, Nawaz Mohsin, Lei Kang, Jiayang Zheng, Zongjie Li, Donghua Shao, Jianchao Wei, Beibei Li, Yafeng Qiu, Zhiyong Ma, Ke Liu
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引用次数: 0
Abstract
Japanese encephalitis virus is mainly prevalent in the tropical and subtropical regions of Asia and Oceania. Through immunoprecipitation-mass spectrometry analysis using monoclonal antibodies targeting JEV E protein, we found that mosquito Histone 2A protein could bind to JEV particles. The binding of H2A and JEV was detected in the salivary gland and supernatant of mosquito cells. Furthermore, RNA interference experiments in vitro and in vivo confirmed that H2A protein promotes JEV infection in mosquitoes. In summary, we found that mosquito H2A is a factor that supports JEV infection and can potentially facilitate cross-species transmission of JEV.
期刊介绍：
Vector-Borne and Zoonotic Diseases is an authoritative, peer-reviewed journal providing basic and applied research on diseases transmitted to humans by invertebrate vectors or non-human vertebrates. The Journal examines geographic, seasonal, and other risk factors that influence the transmission, diagnosis, management, and prevention of this group of infectious diseases, and identifies global trends that have the potential to result in major epidemics.
Vector-Borne and Zoonotic Diseases coverage includes:
-Ecology
-Entomology
-Epidemiology
-Infectious diseases
-Microbiology
-Parasitology
-Pathology
-Public health
-Tropical medicine
-Wildlife biology
-Bacterial, rickettsial, viral, and parasitic zoonoses
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