Effect of endometrial injury on pregnancy outcomes in infertile women undergoing intrauterine insemination.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-04 DOI:10.4274/tjod.galenos.2024.60533

Sedigheh Hosseinimousa, Somayeh Moradpanah, Marzieh Talebian, Reza Pourmahmoudian

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Abstract

Objective: One of the most common treatments for infertility is intrauterine insemination (II). The objective of this study was to determine the effect of endometrial injury on pregnancy outcomes in unexplained infertility in women undergoing II.

Materials and methods: In this randomized clinical trial, 122 women with unexplained infertility who were referred to Shariati Hospital from 2018 to 2020 were enrolled. They underwent ovulation induction using letrozole and gonadotropins. On day 9 of stimulation, they were randomly assigned to two similar groups of the same size. The first group underwent endometrial local injury by pipelle endometrial sampling, and the second group (control group) received no intervention. Only 1 II cycle was performed for each patient. Patients with negative pregnancy outcomes were followed up for 3 months. Endometrial thickness, dominant follicle count, chemical and clinical pregnancy rate, miscarriage rate, and spontaneous pregnancy rate after the II cycle were compared between the two groups.

Results: Endometrial thickness, dominant follicle count, chemical and clinical pregnancy rate, and miscarriage rate in the same II cycle were not different between the two groups (p>0.05). However, the spontaneous pregnancy rate after the II cycle was significantly higher in the endometrial injury group (p=0.02).

Conclusion: Endometrial injury increases pregnancy rates in later cycles but not in the same II cycle.

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子宫内膜损伤对接受宫腔内人工授精的不孕妇女妊娠结局的影响。

目的：宫腔内人工授精（II）是治疗不孕症最常见的方法之一。本研究旨在确定子宫内膜损伤对接受宫腔内人工授精的不明原因不孕症女性妊娠结局的影响：在这项随机临床试验中，共纳入了 2018 年至 2020 年期间转诊至沙里亚蒂医院的 122 名不明原因不孕症女性。她们接受了来曲唑和促性腺激素的促排卵治疗。在促排卵第 9 天，他们被随机分配到两个相同规模的类似组别。第一组通过管状子宫内膜取样进行子宫内膜局部损伤，第二组（对照组）不进行任何干预。每名患者只进行一个 II 周期。对妊娠结果为阴性的患者进行为期 3 个月的随访。比较两组患者的子宫内膜厚度、优势卵泡数、化学和临床妊娠率、流产率以及II周期后的自然妊娠率：结果：两组的子宫内膜厚度、优势卵泡数、化学妊娠率、临床妊娠率和流产率在同一 II 周期中无差异（P>0.05）。然而，子宫内膜损伤组在 II 周期后的自然妊娠率明显更高（P=0.02）：结论：子宫内膜损伤会增加后期周期的妊娠率，但不会增加同一 II 周期的妊娠率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.