Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.

IF 2.1 4区心理学 Q2 PSYCHOLOGY, MULTIDISCIPLINARY Journal of Reproductive and Infant Psychology Pub Date : 2024-03-05 DOI:10.1080/02646838.2024.2324043

Josué Cruz-Rodríguez, Josefa Canals-Sans, Carmen Hernández-Martínez, Victoria Arija

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Abstract

Background: B12 vitamin is essential for the functioning of the nervous system and the production of mood-related neurotransmitters. However, information on its association with postpartum depression (PPD) is limited.

Objective: To examine the effect of serum vitamin B12 levels during pregnancy on PPD, in healthy pregnant women from the Mediterranean region of Catalonia, Spain.

Method: This longitudinal study included a subsample of women at 54 days (7.7 weeks) postpartum (n = 336), who participated in the ECLIPSES Study conducted out in Tarragona, Spain. Maternal concentrations of vitamin B12 were determined in the first and third trimester of pregnancy and sociodemographic, nutritional, and psychological data were collected. PPD was assessed using the Edinburgh Postnatal Depression Scale (EPDS).

Results: The prevalence of probable PPD was 21%. After adjusting for sociodemographic, lifestyle, biochemical parameters, and postpartum characteristics the regression model showed a negative association between EPDS scores and the highest quartile of serum vitamin B12 (first quartile (reference) vs. fourth quartile), (β = -1.267, 95% CI = -2.461, -0.073, p = 0.038).

Conclusion: Maintaining a normal-high level of vitamin B12 during early pregnancy can contributes to preventing PPD.

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孕期维生素 B12 状态与可能的产后抑郁之间的关系：ECLIPSES 研究。

背景：维生素 B12 是神经系统运作和产生与情绪有关的神经递质所必需的物质。然而，有关维生素 B12 与产后抑郁症（PPD）关系的信息却很有限：研究西班牙加泰罗尼亚地中海地区健康孕妇孕期血清维生素 B12 水平对产后抑郁症的影响：这项纵向研究包括产后 54 天（7.7 周）的妇女子样本（n = 336），这些妇女参加了在西班牙塔拉戈纳进行的 ECLIPSES 研究。研究人员在妊娠头三个月和第三个月测定了母体维生素 B12 的浓度，并收集了社会人口、营养和心理数据。PPD 采用爱丁堡产后抑郁量表（EPDS）进行评估：结果：可能患有 PPD 的比例为 21%。在对社会人口学、生活方式、生化参数和产后特征进行调整后，回归模型显示 EPDS 评分与血清维生素 B12 的最高四分位数（第一四分位数（参考值）与第四四分位数）呈负相关，（β = -1.267, 95% CI = -2.461, -0.073, p = 0.038）：结论：在孕早期维持正常的高水平维生素 B12 有助于预防 PPD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Reproductive and Infant Psychology PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

6.80

自引率

8.00%

发文量

期刊介绍： The Journal of Reproductive and Infant Psychology reports and reviews outstanding research on psychological, behavioural, medical and social aspects of human reproduction, pregnancy and infancy. Medical topics focus on obstetrics and gynaecology, paediatrics and psychiatry. The growing work in relevant aspects of medical communication and medical sociology are also covered. Relevant psychological work includes developmental psychology, clinical psychology, social psychology, behavioural medicine, psychology of women and health psychology. Research into psychological aspects of midwifery, health visiting and nursing is central to the interests of the Journal. The Journal is of special value to those concerned with interdisciplinary issues. As a result, the Journal is of particular interest to those concerned with fundamental processes in behaviour and to issues of health promotion and service organization.